… adenosine through the plasma membrane. Also, all compartments are equipped with some
of the adenosine receptors (A1… In terms of intracellular metabolism of adenosine, all cell types …

… In spite of this current mechanistic uncertainty, it seems evident that targeting adenosine
receptors might indeed … This article is part of a Special Issue entitled: "Adenosine Receptors". …

… The functional consequences of activation of the four known adenosine receptors, A 1 , A …
1 -receptor, have been extensively studied using in vitro brain-slice preparations. A 1 -receptor …

… subtype of adenosine receptors can be labeled in bovine brain membranes … brain. The
failure of earlier attempts to labelphysiologically relevant adenosine receptorswith [3H]adenosine (…

… adenosine receptor agonists limit their usefulness in therapeutics; in contrast, adenosine
receptor … Due to the equilibrative adenosine transport across the cell membrane, the levels of …

… Cortex and hippocampus synaptic membranes exhibit higher … and adenosine deaminase
were found in most brain regions [61]. The adenosine receptor subtype dominant in the brain is …

… stimulation of adenosine receptors by extracellular adenosine and adenosine receptor
activation … At the same time, adenosine hyperpolarizes the postsynaptic membrane, restrains …

… Since the conversion from high- to low-molecular weight was achieved by treatment of brain
membranes with adenosine receptor ligands, it is likely that these two forms occur in vivo, …

… This was the starting point for the hypothesis that adenosine was acting through a membrane
receptor antagonized by theophylline, but several years elapsed before the birth of the first …

… , a potent agonist in adenosine-responsive cellular systems, … to identify adenosine binding
sites in rat brain membranes. (-)[… rat brain membranes appear to be equivalent to adenosine …