Background: In the adiponectin gene polymorphisms, single-nucleotide polymorphism
(SNP)− 45 and SNP276 have reportedly been associated with obesity, Type 2 diabetes, and
other features of metabolic syndrome. Aim: Whether these adiponectin SNP affect obesity-
related parameters during caloric restriction in obese subjects. Subjects and methods: Thirty-
two obese Japanese women were treated by meal replacement with a low calorie diet for 8
weeks and asked to maintain their habitual lifestyle. Obesity-related parameters were …

Background. It is generally believed that environmental and genetic factors interact with the
formation of nonalcoholic fatty liver disease (NAFLD) phenotype and determine its
progression. Both NAFLD and type 2 diabetes (T2D) are heterogeneous diseases with
common pathogenic pathways. Adiponectin is an adipokine, which increases the sensitivity
of hepatocytes and muscle to insulin, modulates energy homeostasis, glucose/lipid
metabolism, and inflammatory response. A number of significant adiponectin gene …