Epigenome-wide association in adipose tissue from the METSIM cohort

LD Orozco, C Farrell, C Hale, L Rubbi… - Human molecular …, 2018 - academic.oup.com
… To examine methylation patterns in the METSIM cohort we constructed RRBS libraries from
adipose tissue biopsies, corresponding to 228 individuals. The sequences obtained from …

The causal effect of obesity on prediabetes and insulin resistance reveals the important role of adipose tissue in insulin resistance

Z Miao, M Alvarez, A Ko, Y Bhagat, E Rahmani… - PLoS …, 2020 - journals.plos.org
… from the UK Biobank and the Finnish METSIM cohort, we identified a significant causal effect
… Thus, we further investigated how adipose tissue affects the Matsuda index in the METSIM

Adipose tissue gene expression associations reveal hundreds of candidate genes for cardiometabolic traits

CK Raulerson, A Ko, JC Kidd, KW Currin… - The American Journal of …, 2019 - cell.com
… distribution, and adiposity, although most causal genes remain unknown. We used subcutaneous
adipose tissue RNA-seq data from 434 Finnish men from the METSIM study to identify …

Epigenome-wide association in adipose tissue from the METSIM cohort identifies novel loci and the involvement of adipocytes and macrophages in diabetes traits

LD Orozco, C Farrell, C Hale, L Rubbi, A Rinaldi… - bioRxiv, 2017 - biorxiv.org
… To examine methylation patterns in the METSIM cohort we constructed reduced representation
bisulfite sequencing libraries (RRBS) from adipose tissue biopsies, corresponding to 228 …

ACE2 expression in adipose tissue is associated with cardio-metabolic risk factors and cell type composition—implications for COVID-19

JS El-Sayed Moustafa, AU Jackson… - International Journal of …, 2022 - nature.com
… for the population-based METSIM cohort, composed of 10,197 males of Finnish ancestry [26].
RNA-sequencing of subcutaneous adipose tissue for 426 male participants collected near …

The D299G/T399I Toll-like receptor 4 variant associates with body and liver fat: results from the TULIP and METSIM Studies

P Weyrich, H Staiger, A Stančáková, F Machicao… - PloS one, 2010 - journals.plos.org
… intake and endogenous SFFAs derived from adipose tissue lipolysis, respectively, to inflammation.
… We additionally stratified the TÜF/TULIP cohort for gender, as the METSIM cohort only …

[HTML][HTML] ACE2 expression in adipose tissue is associated with COVID-19 cardio-metabolic risk factors and cell type composition

JSES Moustafa, AU Jackson, SM Brotman, L Guan… - medRxiv, 2020 - ncbi.nlm.nih.gov
… Cis-eQTL and genome-wide association analyses of adipose tissue ACE2 expression
from the TwinsUK, METSIM and FUSION cohorts were meta-analysed using the sample-size …

Gut microbe-derived metabolites and the risk of cardiovascular disease in the METSIM cohort

S Mirzaei, HA DeVon, RM Cantor, A Cupido… - Frontiers in …, 2024 - frontiersin.org
… -derived metabolites based on their availability in the METSIM cohort. We excluded gut-derived …
The data of the METSIM participants were linked to several Finnish registries, including a …

Differential associations of inflammatory markers with insulin sensitivity and secretion: the prospective METSIM study

M Fizelova, R Jauhiainen, AJ Kangas… - The Journal of …, 2017 - academic.oup.com
… The cross-sectional and follow-up studies of the METSIM cohort used identical protocols
and similar clinical and laboratory measurements. All clinical and laboratory measurements …

Relationships and Mendelian Randomization of Gut Microbe-Derived Metabolites with Metabolic Syndrome Traits in the METSIM Cohort

S Mirzaei, HA DeVon, RM Cantor, AJ Cupido, C Pan… - Metabolites, 2024 - mdpi.com
The role of gut microbe-derived metabolites in the development of metabolic syndrome (MetS)
remains unclear. This study aimed to evaluate the associations of gut microbe-derived …