The importance of adjuvant formulation in the development of a tuberculosis vaccine

SL Baldwin, S Bertholet, VA Reese… - The Journal of …, 2012 - journals.aai.org
… However, this adjuvant formulation fails to increase … vaccine Ag, ID93, combined with two
adjuvant formulations can lead to two different outcomes. ID93 combined with the Th1 adjuvant, …

Novel adjuvant formulations for delivery of anti-tuberculosis vaccine candidates

EM Agger - Advanced drug delivery reviews, 2016 - Elsevier
… such as viral vectored- or protein-based vaccines. The use of recombinant … an adjuvant
inducing cell-mediated immune responses. A number of promising novel adjuvant formulations

Adjuvant strategies for more effective tuberculosis vaccine immunity

E Stewart, JA Triccas, N Petrovsky - Microorganisms, 2019 - mdpi.com
… Liposomes are lipid-based vesicles that self-assemble through hydrophobic interaction,
forming microparticles able to carry different vaccine or adjuvant formulations [20]. One of the …

Developing new anti-tuberculosis vaccines: focus on adjuvants

AR Franco, F Peri - Cells, 2021 - mdpi.com
… Subunit vaccines are promising candidates since they can … , these vaccines need adjuvants
in their formulation in order to … on adjuvants being used in new formulations of TB vaccines, …

Adjuvant formulation structure and composition are critical for the development of an effective vaccine against tuberculosis

MT Orr, CB Fox, SL Baldwin, SJ Sivananthan… - Journal of Controlled …, 2013 - Elsevier
adjuvant formulations containing the TLR4 agonist GLA to identify candidate adjuvants to pair
with ID93, a lead TB vaccine … We evaluate a variety of adjuvant formulations including alum…

Adjuvants in tuberculosis vaccine development

SA Moreno-Mendieta, L Rocha-Zavaleta… - FEMS Immunology & …, 2010 - academic.oup.com
… the current state of adjuvant development and its impact on tuberculosis vaccine progress. …
for human use remains a challenge and is equally important to subunit vaccine formulation as …

Vaccine adjuvant: it makes the difference

KM Lima, SA dos Santos, JM Rodrigues Jr, CL Silva - Vaccine, 2004 - Elsevier
… However, in these cases, the use of adjuvant is frequently required to improve their …
importance of the adjuvant in a vaccine formulation. Vaccines for tuberculosis provide an instructive …

Enhanced immunogenicity of BCG vaccine by using a viral-based GM-CSF transgene adjuvant formulation

J Wang, A Zganiacz, Z Xing - Vaccine, 2002 - Elsevier
… The failure of current BCG vaccine in controlling the global tuberculosis (TB) epidemic …
-based adjuvant formulation is an effective way to improve the immunogenicity of BCG vaccine. …

Improving vaccine performance with adjuvants

FR Vogel - Clinical Infectious Diseases, 2000 - academic.oup.com
… virus (HIV) and tuberculosis. Several of these … , adjuvant formulations can be designed that
favor the development of T-helper type 1 (Th1) or type 2 (Th2) immune responses to vaccine

Role of Fused Mycobacterium tuberculosis Immunogens and Adjuvants in Modern Tuberculosis Vaccines

AP Junqueira-Kipnis, LM Marques Neto… - Frontiers in …, 2014 - frontiersin.org
… of adjuvants in the vaccine formulation. The fusion of adjuvants with Mycobacterium tuberculosis
(… the new frontier in the TB vaccine development field. Researchers have addressed this …