Clinical evaluation of CpG oligonucleotides as adjuvants for vaccines targeting infectious diseases and cancer

J Scheiermann, DM Klinman - Vaccine, 2014 - Elsevier
… Results indicate that CpG ODN improve antigen presentation and the generation of vaccine-…
of the utility of CpG ODN as adjuvants for vaccines targeting infectious agents and cancer. …

CpG oligonucleotides as adjuvants for vaccines targeting infectious diseases

DM Klinman, S Klaschik, T Sato, D Tross - Advanced drug delivery reviews, 2009 - Elsevier
… by vaccines. The current contribution will review evidence that synthetic phosphorothioate
CpG oligonucleotides (ODN) can accelerate, boost and improve the durability of vaccine-…

CpG oligonucleotides as cancer vaccine adjuvants

H Shirota, D Tross, DM Klinman - Vaccines, 2015 - mdpi.com
CpGCpG ODN stimulation was verified in studies using CpG-Ag complexes to enhance
Ag-specific class switching in vivo and supports the use of CpG ODN as adjuvants for vaccines

CpG oligonucleotides as vaccine adjuvants

N Kayraklioglu, B Horuluoglu, DM Klinman - DNA Vaccines: Methods and …, 2021 - Springer
CpG ODN were effective as vaccine adjuvants in multiple species. CpG ODN adjuvanted
AVA induced a rapid and protective toxin-neutralizing Ab response in guinea pigs [113]. Calves …

CpG oligonucleotides as adjuvant in therapeutic vaccines against parasitic infections

S Zimmermann, A Dalpke, K Heeg - International Journal of Medical …, 2008 - Elsevier
… Novel Vaccination Strategies”, we set out to analyze various aspects of CpG oligonucleotide
(CpG-ODN) vaccination … , eg differences between prophylactic and therapeutic vaccinations. …

CpG oligonucleotides as immune adjuvants

AM Krieg - Therapeutic Vaccination Strategies, 2000 - Springer
… Applications of CpG DNA in Vaccination The utility of CpG DNA as a vaccine adjuvant is …
be suspected of acting as an adjuvant, the fact that CpG DNA synergizes so strongly with B cell …

Recent progress concerning CpG DNA and its use as a vaccine adjuvant

H Shirota, DM Klinman - Expert review of vaccines, 2014 - Taylor & Francis
… with the ability of CpG ODN to act as vaccine adjuvants, inducing … Thus, CpG ODN can be
used as a vaccine adjuvant to trigger … of receptor interaction with CpG oligonucleotides (ODN) …

CpG-containing oligonucleotides are efficient adjuvants for induction of protective antiviral immune responses with T-cell peptide vaccines

A Oxenius, MMA Martinic, H Hengartner… - Journal of …, 1999 - Am Soc Microbiol
… the adjuvant. B cells were not required for induction of protective CTL responses by
peptide–CpG-ODN immunization … Thus, the local application of CpG-ODN induced probably a …

Formulation of vaccines containing CpG oligonucleotides and alum

JA Aebig, GED Mullen, G Dobrescu, K Rausch… - Journal of …, 2007 - Elsevier
… -based vaccines, the immunostimulatory effect of CpG depends on the association of the
CpG and … dissociates suggests that CpG may not be an effective adjuvant for these alum-based …

Immunostimulatory CpG oligonucleotides: Effect on gene expression and utility as vaccine adjuvants

DM Klinman, S Klaschik, K Tomaru, H Shirota, D Tross… - Vaccine, 2010 - Elsevier
CpG ODN are finding use as vaccine adjuvants, where they increase the speed, magnitude
and duration of vaccine… the ability of CpG ODN to act as vaccine adjuvants. As exemplified by …