Design, synthesis, mechanistic studies and in silico ADME predictions of benzimidazole derivatives as novel antifungal agents

MM Morcoss, MN El Shimaa, RA Ibrahem… - Bioorganic …, 2020 - Elsevier
… The study was expanded to forecast the mechanism of action … In silico ADME prediction
investigations also forecasting the … The outcomes of the predicted ADME parameters are shown …

[HTML][HTML] In Silico ADME and toxicity prediction of benzimidazole derivatives and its cobalt coordination compounds. synthesis, characterization and crystal structure

A Raducka, M Świątkowski, K Gobis, P Szymański… - Molecules, 2022 - mdpi.com
… cobalt coordination compounds with non-commercial benzimidazole derivatives. Our work
is a … The choice fell on benzimidazole derivatives due to the wide spectrum of activity, and in …

Synthesis, ADMET, drug likeness and in silico activities of benzimidazole derivative

A Agrwal, R Saini, S Bhandri, S Verma… - Materials Today …, 2022 - Elsevier
… structure of synthesized benzimidazole derivatives were drawn using … predictions were
done using DATA Warrior and Swiss ADME, the “molecular docking activity” of all the derivatives

Synthesis, molecular docking and ADME prediction of some new benzimidazole carboxamidines derivatives as antimicrobial agents

M Erol, I Celik, O Temiz-Arpaci, H Goker… - Medicinal Chemistry …, 2020 - Springer
… In this study, 15 new 1H-benzimidazole-5-carboxamidine derivative compounds that could …
of the new benzimidazole derivatives were weaker than standard drugs, but some derivatives

[PDF][PDF] QSAR, molecular docking and ADME studies of benzimidazole derivatives as antibacterial agents

V Kumar - European Chemical Bulletin, 2023 - researchgate.net
… , and ADME studies of benzimidazole derivatives against Escherichia … The antibacterial
activity of benzimidazole derivatives is … and ADME Studies for the prediction of Benzimidazole

[HTML][HTML] Design, synthesis, ADME prediction and pharmacological evaluation of novel benzimidazole-1, 2, 3-triazole-sulfonamide hybrids as antimicrobial and …

FF Al-Blewi, MA Almehmadi, MR Aouad… - Chemistry Central …, 2018 - Springer
… , benzimidazole and sulfonamides moieties in one scaffold via a Cu(I)-catalysed 1,3-dipolar
cycloaddition reaction of sulfa drug azides with propargylated benzimidazoles derivatives

Synthesis, molecular modeling, quantum mechanical calculations and ADME estimation studies of benzimidazole-oxadiazole derivatives as potent antifungal agents

UA Çevik, I Celik, A Işık, RR Pillai, TE Tallei… - Journal of Molecular …, 2022 - Elsevier
benzimidazole derivatives can be CYP51 inhibitors [13], [14], [15], [16]. Furthermore, ADME
… In this study, we predict MM-PBSA through the different energy parameters such as Van der …

Design, synthesis and ADMET prediction of bis-benzimidazole as anticancer agent

M Rashid - Bioorganic chemistry, 2020 - Elsevier
… was also used to estimate ADME and toxicity of synthetic … bis-benzimidazole derivatives
and predict their physiochemical … explorer, Pre ADMET prediction and Lazar toxicity prediction. …

Synthesis, in vitro cytotoxicity, ADME, and molecular docking studies of benzimidazole‐bearing furanone derivatives

A Husain, M Bhutani, S Parveen… - Journal of the …, 2021 - Wiley Online Library
… carbenes; benzimidazole-based piperidine derivatives and … of furanone derivatives containing
benzimidazole core and their … ADME predictions and in silico pharmacokinetic properties …

[PDF][PDF] Synthesis, molecular docking, in silico ADME and antimicrobial activity studies of some new benzimidazole-triazole derivatives

AE Evren, İ Çelik, UA Çevik - Cumhuriyet Science Journal, 2021 - dergipark.org.tr
… In this study, 10 new triazole bearing benzimidazole derivatives were designed and synthesized,
and their structures were elucidated by IR, 1H NMR, 13C NMR, mass spectral analysis, …