… Many of these molecules constitute successful therapeutic targets (Figure 1). Targeted
Therapies and Their Proposed Mechanisms of Action Direct evidence for the pathogenetic …

… that continues to expand as our knowledge of epigenetic regulation advances. Epigenetic
… These advances may limit the side effects of treatment, improving compliance with dosing …

… on their advantages and limitations. Mouse cancer models are … rapid advances in human
and veterinary cancer therapies by … the current knowledge about therapeutic targets that play a …

… Despite recent improvements in the research of mTOR signaling in cells, notably its
development as a therapeutic target for cancer treatment, more work must be done to completely …

… of DNA alterations seen in advanced PCa. DESIGN, SETTING, AND … RESULTS AND
LIMITATIONS: We obtained an average sequencing … the genomic landscape within advanced …

… Additionally, anti-oxidative activity could be an important therapeutic target for patients with
… associated with ALS, and could be a promising therapeutic target for the treatment of ALS. …

… imposes limitations in maneuvering it as therapeutic target for … target with emerging challenges’,
along with the limitations … With the advancement of technology and thereby more clear …

… Here, we limit the discussion to two aspects of transcriptional target gene dysregulation
in … targets of the fusion proteins as therapeutic targets, a third area of recent advances. …

… -care burden, despite recent treatment advances. The key … Here, we review recent advances
in our understanding of … that might be suitable targets for therapeutic manipulation. Such …

… advanced solid tumors. The pleiotropic roles and ubiquitous expression of the protein can be
viewed as limitations … considered as a potential therapeutic target for improving the clinical …