… effect associated with statin pharmacotherapy. … statin adverse effects. This contemporary
review of the relevant clinical research on polymorphisms in several key genes that affect statin …

… can vary greatly amongst patients receiving the same dose of a statin, for example a recent
… of the pharmacogenomics in statin response (both beneficial and harmful effects) have …

… therapy is relatively well tolerated, with mild dyspepsia and gastrointestinal discomfort
accounting for the majority of reported adverse reactions, more severe reactions can occur, …

… markers related to statin-induced … statins, which, in turn, contributes to the regulation of
plasma levels of SLCO1B1) were strongly associated with statin-induced muscular adverse effects…

… This review focused on the pharmacogenetics of statins, including cytochrome P450
enzymes (CYP2C9, CYP3A4 and CYP3A5), uptake (SLCO1B1) and efflux transporters (ABCB1, …

… to altering the pharmacodynamic profile of statins. Pharmacogenetics and its application in
… with a poor response to statin therapy or statin-associated adverse effects.[74] Regarding …

… adverse drug reactions has been less, but some important associations, such as those of
SLCO1B1 and statin … As the area of non-HLA genetic associations in adverse reactions covers …

… and pharmacodynamics of statins and in disease-modifying … genes for pharmacogenomic
analysis of statin therapy are HMG… For individuals at high risk for statin side effects such as …

… Moreover, the drug disposition pathways differ between statins. More efficient strategies …
to serious adverse events such as myositis, as well as the cost-effectiveness of statin therapy …

… large statin trials could be expected for the near future. In contrast to the pharmacogenomics
of adverse effects of statin therapy, some genetic polymorphisms influencing statin efficacy …