… status, the hazard ratios for erlotinib over placebo being 0.55 (p = … Both gefitinib and erlotinib
were developed as EGFR … have yet compared gefitinib and erlotinib for adverse events (AEs…

… MST compared with gefitinib and icotinib (P<0.05). In conclusion, gefitinib, erlotinib and
icotinib … However, gefitinib resulted in a lower frequency of fatigue, and nausea and vomiting, …

… Gefitinib and erlotinib are reversible EGFR TKIs, whereas … a direct comparison of gefitinib
versus erlotinib in the first-line … over gefitinib but higher drug-related severe adverse events (…

… examining the adverse events and tolerances of 250 mg daily gefitinib and 150 mg daily
erlotinib in … Adverse events were assessed according to Common Terminology Criteria for …

… trials of gefitinib reported difference profiles in adverse events compared to those of erlotinib.
… hypothesis is that there may be some differences in adverse event of gefitinib and erlotinib. …

… Surprisingly, even grade 3–4 adverse events (AEs) have been largely ignored because the
… that gefitinib and erlotinib have comparable tolerability and clinical activity and that gefitinib …

… erlotinib is seven times higher than that of gefitinib.8, 13 These differences have led to the
assumption that erlotinib … more adverse events than gefitinib. Indeed, studies have shown that …

… similar adverse events except for dermal side effects such as … %) for erlotinib and 20.6,
26.5 and 29.4 per cent for gefitinib, … the effectiveness of erlotinib and gefitinib. There was no …

… Toxicities were assessed by the investigators based on the incidence and severity of
adverse events (AEs), according to the National Cancer Institute Common Toxicity Criteria (NCI …

… management of adverse events may in part contribute to the longer PFS. We note that the
rate of total grade 3 or 4 adverse events for afatinib, gefitinib, and erlotinib were approximately …