[HTML][HTML] Management of adverse events associated with tyrosine kinase inhibitors: improving outcomes for patients with hepatocellular carcinoma

L Rimassa, R Danesi, T Pressiani, P Merle - Cancer Treatment Reviews, 2019 - Elsevier
… All these agents are associated with a range of adverse events (AEs) that can have a …
adverse events in phase 3 trials of tyrosine kinase inhibitors in advanced hepatocellular carcinoma

Prognostic significance of adverse events in patients with hepatocellular carcinoma treated with sorafenib

A Granito, S Marinelli, G Negrini… - Therapeutic …, 2016 - journals.sagepub.com
… Sorafenib is the standard treatment for patients with hepatocellular carcinoma (HCC) with …
assessing the prognostic significance of sorafenib-related adverse events is provided. …

[HTML][HTML] Adverse events of sorafenib in hepatocellular carcinoma treatment

Y Pang, A Eresen, Z Zhang, Q Hou… - American Journal of …, 2022 - ncbi.nlm.nih.gov
… of the patients with surgically unresectable hepatocellular carcinoma (HCC). Sorafenib …
In this review, we discussed the mechanism of sorafenib-associated adverse events and …

Management of adverse events with tailored sorafenib dosing prolongs survival of hepatocellular carcinoma patients

F Tovoli, L Ielasi, A Casadei-Gardini, A Granito… - Journal of …, 2019 - Elsevier
… for hepatocellular carcinoma for over a decade. Its tolerability is limited by different adverse
events… physicians’ experience in managing adverse events related to sorafenib has improved …

Association between overall survival and adverse events with lenvatinib treatment in patients with hepatocellular carcinoma (REFLECT).

MW Sung, RS Finn, S Qin, KH Han, K Ikeda, AL Cheng… - 2019 - ascopubs.org
… The most common adverse events (AEs) in pts treated with LEN were hypertension and
diarrhea. In addition, LEN showed a different AE profile from that of SOR. Pts who received LEN …

Adverse events as potential predictive factors of activity in patients with advanced hepatocellular carcinoma treated with lenvatinib

IG Rapposelli, T Tada, S Shimose, V Burgio… - Liver …, 2021 - Wiley Online Library
Background and Aim Lenvatinib is a standard of care option in first‐line therapy of advanced
hepatocellular carcinoma (HCC). In the present study, we aim to identify, in patients with …

Impact of immune-related adverse events on efficacy of immune checkpoint inhibitors in patients with advanced hepatocellular carcinoma

KYY Ng, SH Tan, JJE Tan, DSH Tay, AWX Lee… - Liver Cancer, 2022 - karger.com
… Introduction: Development of immune-related adverse events (irAEs) has been associated
… such an association exists in advanced hepatocellular carcinoma (aHCC). This study aims to …

[HTML][HTML] Clinical significance of adverse events for patients with unresectable hepatocellular carcinoma treated with lenvatinib: a multicenter retrospective study

S Shimose, H Iwamoto, T Niizeki, T Shirono, Y Noda… - Cancers, 2020 - mdpi.com
… with the discontinuation of lenvatinib (LEN) due to severe adverse events (DLSAE) in patients
with unresectable hepatocellular carcinoma (HCC). This retrospective study enrolled 177 …

Therapeutic potential and adverse events of everolimus for treatment of hepatocellular carcinoma–systematic review and meta‐analysis

K Yamanaka, M Petrulionis, S Lin, C Gao… - Cancer …, 2013 - Wiley Online Library
adverse events have been pointed out. This review summarizes the antitumor effects and
adverse events … For the meta-analysis of adverse events, we used the RCTs for solid cancers. …

[HTML][HTML] Correlation between immune-related adverse events and prognosis in hepatocellular carcinoma patients treated with immune checkpoint inhibitors

S Xu, R Lai, Q Zhao, P Zhao, R Zhao… - Frontiers in immunology, 2021 - frontiersin.org
… and ICI efficacy in hepatocellular carcinoma (HCC) patients. … The most frequent adverse
event was diarrhea/colitis (n = 6), and the … There was no grade 3 adverse event observed in our …