… show that this mutation occurs more frequently in patients with PTC showing aggressive …
evaluate the prevalence of the BRAF V600E mutation in tumor samples and its association …

… BRAF V600E mutation represents the most common oncogenic event in sporadic papillary
thyroid cancer (PTC… Moreover, the impact of BRAF V600E mutants on tumour-related patient's …

… A high prevalence of the BRAF V600E somatic mutation was recently reported in several
series of papillary thyroid carcinomas (PTC). This mutation appears to be particularly prevalent …

… might lead to the progression of DTC to the more aggressive thyroid cancer, and … maintains
proliferation, transformation, and tumorigenicity of BRAFmutant papillary thyroid cancer cells. …

… The BRAF mutation reported recently in thyroid carcinomas … the BRAF V600E mutation was
found in 50% of high aggressive … high aggressive tumors arise in a significant subset of BRAF …

… PTMC is a type of papillary thyroid carcinoma (PTC) with a maximum diameter of 1.0 cm or
less.4 Advances in ultrasonographic (US) screening and US-guided fine-needle aspiration …

… The aggressive pathogenic role of BRAF mutation in human PTC was completely reproduced
in transgenic mice in which targeted over-expression or endogenous expression of the …

… In this study, BRAF V600E mutation was associated with aggressive disease in small
papillary thyroid carcinoma ≤ 1.5 cm and papillary thyroid microcarcinoma ≤ 1 cm, defined by: …

… , as well as BRAF V600E mutation–positive PTC. … that BRAF V600E and TERT C228T
mutations may cooperatively form a unique genetic background that identifies the most aggressive …

… The tall cell variant is often refractory to such treatment but may be susceptible to treatment
targeted against BRAF mutation. External beam irradiation may be used in cases of …