BRAFV600E Mutation is Associated with Tumor Aggressiveness in Papillary Thyroid Cancer

S Kim, KE Lee, JP Myong, J Park, YK Jeon… - World journal of …, 2012 - Springer
… show that this mutation occurs more frequently in patients with PTC showing aggressive
evaluate the prevalence of the BRAF V600E mutation in tumor samples and its association …

BRAF mutation associated with other genetic events identifies a subset of aggressive papillary thyroid carcinoma

AM Costa, A Herrero, MF Fresno… - Clinical …, 2008 - Wiley Online Library
BRAF V600E mutation represents the most common oncogenic event in sporadic papillary
thyroid cancer (PTC… Moreover, the impact of BRAF V600E mutants on tumour-related patient's …

Type and prevalence of BRAF mutations are closely associated with papillary thyroid carcinoma histotype and patients' age but not with tumour aggressiveness

V Trovisco, P Soares, A Preto, IV de Castro, J Lima… - Virchows Archiv, 2005 - Springer
… A high prevalence of the BRAF V600E somatic mutation was recently reported in several
series of papillary thyroid carcinomas (PTC). This mutation appears to be particularly prevalent …

BRAF mutation in papillary thyroid carcinoma: pathogenic role and clinical implications

KT Tang, CH Lee - Journal of the chinese medical association, 2010 - journals.lww.com
… might lead to the progression of DTC to the more aggressive thyroid cancer, and … maintains
proliferation, transformation, and tumorigenicity of BRAFmutant papillary thyroid cancer cells. …

Analysis of Differential BRAFV600E Mutational Status in High Aggressive Papillary Thyroid Microcarcinoma

X Lee, M Gao, Y Ji, Y Yu, Y Feng, Y Li, Y Zhang… - Annals of surgical …, 2009 - Springer
… The BRAF mutation reported recently in thyroid carcinomas … the BRAF V600E mutation was
found in 50% of high aggressive … high aggressive tumors arise in a significant subset of BRAF

The BRAF Mutation Is Predictive of Aggressive Clinicopathological Characteristics in Papillary Thyroid Microcarcinoma

KL Lin, OC Wang, XH Zhang, XX Dai, XQ Hu… - Annals of surgical …, 2010 - Springer
… PTMC is a type of papillary thyroid carcinoma (PTC) with a maximum diameter of 1.0 cm or
less.4 Advances in ultrasonographic (US) screening and US-guided fine-needle aspiration …

Prognostic utility of BRAF mutation in papillary thyroid cancer

M Xing - Molecular and cellular endocrinology, 2010 - Elsevier
… The aggressive pathogenic role of BRAF mutation in human PTC was completely reproduced
in transgenic mice in which targeted over-expression or endogenous expression of the …

BRAFV600E mutation is associated with aggressive features in papillary thyroid carcinomas ≤ 1.5 cm

JA Silver, M Bogatchenko… - … -Head & Neck …, 2021 - journals.sagepub.com
… In this study, BRAF V600E mutation was associated with aggressive disease in small
papillary thyroid carcinoma ≤ 1.5 cm and papillary thyroid microcarcinoma ≤ 1 cm, defined by: …

BRAF V600E and TERT Promoter Mutations Cooperatively Identify the Most Aggressive Papillary Thyroid Cancer With Highest Recurrence

M Xing, R Liu, X Liu, AK Murugan, G Zhu… - Journal of clinical …, 2014 - ascopubs.org
… , as well as BRAF V600E mutation–positive PTC. … that BRAF V600E and TERT C228T
mutations may cooperatively form a unique genetic background that identifies the most aggressive

Aggressive variants of papillary thyroid carcinoma

CE Silver, RP Owen, JP Rodrigo, A Rinaldo… - Head & …, 2011 - Wiley Online Library
… The tall cell variant is often refractory to such treatment but may be susceptible to treatment
targeted against BRAF mutation. External beam irradiation may be used in cases of …