… Deposition of β-amyloid (Aβ) and vascular brain injury (VBI) are the 2 most common
pathologic changes seen in the aging brain. They frequently co-occur 1 ; however, determining …

… in understanding relationships between Alzheimer and vascular diseases. Neuroimaging
has long helped us to detect and quantify brain vascular diseases. The more recent advent of …

… to vessel injury, and predispose elderly individuals to vascular disease. … to contribute to
vascular injury during atherosclerosis. … of angiogenic factors in the aged brain after stroke.60 …

… For example, aging within blood vessels contributes to a decrease in blood flow to important
… system, cerebral vascular aging can lead to loss of the integrity of the blood-brain barrier, …

… progression suggest that BBB dysfunction contributes to brain aging [40]. Lee et al [41] …
brain injury. They found evidence for a post-injury increase in BBB permeability in the aged brain…

… inflammation and oxidative stress, enhancing the vascular response to injury and
rendering the aged vascular wall susceptible to atherogenesis. Activation of RAS/increased …

… aging brain to injury are likely to contribute substantially to this population's poorer trajectory
of recovery compared with that observed in younger patients. Although neuroradiological …

… It is common knowledge that brain is particularly vulnerable to both traumatic injury and age-…
Traumatic Brain Injury The sensitivity to brain vasculature to traumatic injury is different from …

… In this review we focus our attention on the evidence of oxidative stress in aging brain,
some of the most important neurodegenerative diseases – Alzheimer's disease (AD), mild …

… and aging share similar mechanisms of vascular dysfunction. In fact, vascular remodelling,
endothelial dysfunction and vascular … to vascular injury in the resistance vasculature [20]. …