Protective effect of flavonoids against aging-and lipopolysaccharide-induced cognitive impairment in mice

CS Patil, VP Singh, PSV Satyanarayan, NK Jain… - Pharmacology, 2003 - karger.com
mice did not show any improvement of memory retention in … in both young and aged mice;
however, aged mice showed … reverses cognitive deficits in aged and LPS-intoxicated mice

Chronic social stress during adolescence induces cognitive impairment in aged mice

V Sterlemann, G Rammes, M Wolf, C Liebl… - …, 2010 - Wiley Online Library
… stressed mice. Finally… cognitive impairment during aging, demonstrating the detrimental
impact of stress during adolescence on hippocampus-dependent cognitive function in aged mice

Trimethylamine‐N‐oxide promotes brain aging and cognitive impairment in mice

D Li, Y Ke, R Zhan, C Liu, M Zhao, A Zeng, X Shi… - Aging cell, 2018 - Wiley Online Library
… dysfunction in SAMR1 and SAMP8 mice, respectively. Our … brain aging and age-related
cognitive dysfunction in SAMR1 mice and aggravate the cerebral aging process of SAMP8 mice, …

High fat diet increases hippocampal oxidative stress and cognitive impairment in aged mice: implications for decreased Nrf2 signaling

CD Morrison, PJ Pistell, DK Ingram… - Journal of …, 2010 - Wiley Online Library
… that HFD consumption impairs cognitive function in aged mice, and that this cognitive
impairment is specifically associated with increased protein oxidation and impaired Nrf2 signaling. …

Age-related cognitive impairment is associated with long-term neuroinflammation and oxidative stress in a mouse model of episodic systemic inflammation

JC d'Avila, LD Siqueira, A Mazeraud… - Journal of …, 2018 - Springer
… that aged mice have increased susceptibility to episodic systemic inflammation. Aged mice
that showed cognitive impairments also … mechanisms of age-related cognitive impairments. …

Obesity-induced neuroinflammation and cognitive impairment in young adult versus middle-aged mice

RE Henn, SE Elzinga, E Glass, R Parent, K Guo… - Immunity & …, 2022 - Springer
cognitive impairment by training mice to associate a context and tone with a foot-shock. All
mice … However, HFD mice, particularly aged HFD mice, exhibited higher levels of freezing …

17β-estradiol modulates SIRT1 and halts oxidative stress-mediated cognitive impairment in a male aging mouse model

M Khan, R Ullah, SU Rehman, SA Shah, K Saeed… - Cells, 2019 - mdpi.com
… , ultimately leading to cognitive impairment. In this study, we … -mediated cognitive dysfunction
in a male mouse model. The … dysfunction and memory impairment in adult mouse brains. …

Visceral adiposity links cerebrovascular dysfunction to cognitive impairment in middle-aged mice

O Pétrault, M Pétrault, T Ouk, R Bordet… - Neurobiology of …, 2019 - Elsevier
… A cohort of 216 young mice was fed with HFD up to middle … mice according to their
heterogeneous response to diet, and to propose a statistical prediction model for cognitive

Protective effects of sesamol on systemic inflammation and cognitive impairment in aging mice

B Ren, T Yuan, X Zhang, L Wang, J Pan… - Journal of agricultural …, 2020 - ACS Publications
… HFD-fed ApoE gene knockout mice. (21) Thus, in this study, we evaluated the neuroprotective
function of sesamol on aging-triggered cognitive impairments in mice and the relationship …

Ligustilide prevents cognitive impairment and attenuates neurotoxicity in D-galactose induced aging mice brain

JJ Li, Q Zhu, YP Lu, P Zhao, ZB Feng, ZM Qian, L Zhu - Brain research, 2015 - Elsevier
… to prevent the aging process in d-gal treated mice brain. In the present study, we investigated
the protective effect of LIG on cognitive impairment and neurotoxicity in aging mice brain …