[PDF][PDF] From ancient pathways to aging cells—connecting metabolism and cellular senescence

CD Wiley, J Campisi - Cell metabolism, 2016 - cell.com
… or rapamycin and cellular senescence suggest mechanisms … , cell signaling, and cell fates,
particularly cellular senescence, … that occurs during cellular senescence (Figure 3) is still in …

Cell senescence: role in aging and age-related diseases

J Campisi, L Robert - Aging, 2014 - karger.com
pathway, enabling them to escape malignancy. The senescent cell became a major actor of
the aging process, among others, by the acquisition of the senescence-associated secretory …

Molecular signaling and genetic pathways of senescence: its role in tumorigenesis and aging

H Zhang - Journal of cellular physiology, 2007 - Wiley Online Library
senescence, including the signals that trigger senescence, the molecular pathways by which
cells enter senescence, and evidence that supports its role in tumorigenesis and aging. J. …

ROS, cell senescence, and novel molecular mechanisms in aging and age‐related diseases

P Davalli, T Mitic, A Caporali… - … medicine and cellular …, 2016 - Wiley Online Library
… ability of inducing cell senescence through novel mechanisms that underpin aging processes.
… models have advanced our understanding of pathways that lead to age-related features, …

The signals and pathways activating cellular senescence

I Ben-Porath, RA Weinberg - … international journal of biochemistry & cell …, 2005 - Elsevier
… Once cells have entered senescence, they cease to divide and … Cellular senescence is
thought to play an important role in tumor suppression and to contribute to organismal aging, but …

[PDF][PDF] Biology of cancer and aging: a complex association with cellular senescence

C Falandry, M Bonnefoy, G Freyer, E Gilson - Journal of Clinical Oncology, 2014 - Citeseer
… of stem cells during aging, thus providing the basis for aging-… of aging phenotypes from
bacteria to humans, aging pathways … Targeting older cells, aging pathways, and particularly those …

Cell senescence in the aging kidney

H Yang, AB Fogo - Journal of the American Society of Nephrology, 2010 - journals.lww.com
aging kidney. Here we discuss new progress in understanding renal aging, focusing on
mechanisms of cell senescence … , all pathways associated with alleviating cell senescence in the …

Telomere and its role in the aging pathways: telomere shortening, cell senescence and mitochondria dysfunction

Y Zhu, X Liu, X Ding, F Wang, X Geng - Biogerontology, 2019 - Springer
aging through multiple pathways. In this review, we summarized the main mechanisms of
cellular senescence, mitochondrial malfunction and aging … involved in the aging process may …

CSGene: a literature-based database for cell senescence genes and its application to identify critical cell aging pathways and associated diseases

M Zhao, L Chen, H Qu - Cell death & disease, 2016 - nature.com
cell senescence genes in a pathway context, we extracted PPIs between 504 cell senescence
… This provides a broader biological picture associated with cell aging. To this end, a non-…

Mitochondrial dysfunction in cell senescence and aging

S Miwa, S Kashyap, E Chini… - The Journal of clinical …, 2022 - Am Soc Clin Investig
… we summarize pathways that cause mitochondrial dysfunction in senescence and aging and
… these consequences contribute to senescence and aging. We also highlight the potential of …