… Dysregulation of cell cycle, oxidative stress, altered calcium signaling, hyperuricemia, and …
of EC senescence and vascular disease in aging. A number of abnormal molecular pathways …

… It will be interesting to target other stress support pathways of senescent cells to utilize
non-senescence addiction for senotherapy. To expand this concept, it is possible to seek for …

… acquisition of senescence associated … of cellular senescence including replicative senescence
(RS) which occurs due to telomere shortening and stress induced premature senescence …

This review article addresses the largely unanticipated convergence of two landmark
discoveries. The first is the discovery of interferons, critical signaling molecules for all aspects of …

… in T cell differentiation and aging are shared. ► The cytokine milieu in the aging host … The
aging T cell is biased towards negative regulatory pathways. ► Negative regulatory receptors (…

… Cellular senescence is a hallmark of aging defined by stable exit from the cell cycle in
response to cellular … Both intracellular senescence-associated pathways and extracellular …

… While cellular senescence in peripheral tissues has recently been linked … aging is just
beginning to be explored. Recent data generated by several laboratories suggest that both aging …

… Such findings have prompted studies to delineate fine differences in pathways leading to
apoptosis, cellular senescence and cancer for therapeutic analysis, as well as to decelerate the …

… Additional pathways may trigger cellular senescence in melanocytes and keratinocytes
within the basal layer and keratinocytes within the suprabasal layer. The resulting pro-oxidant …

… Senescence emerges during the aging process in several … shows that cellular senescence
is implicated in aging-related … , many signaling pathways are involved in cellular senescence, …