… 2 and 7 in a replicative aging model cause senescence of dermal fibroblasts (16). … aging
promotes cellular senescence in human umbilical cord-derived MSCs via the p53/p21 pathway …

… and aging, eg, p16 Ink4a , p19 Arf , TNFα, JNK, … pathway [19] for example, hypertension
induces the cell cycle inhibitor, p16 Ink4a which is a characteristic of somatic cell senescence …

… in which cellular stress and preadipocyte overutilization with aging induce cellular senescence,
… secretory state related to the molecular pathways that initiate senescence in dividing cell …

… the process of “cellular aging”: the progression of internal changes occurring in primary
cells leading to the induction of cellular senescence and culminating in cell death. Phenotypic …

… Cellular senescence is a hallmark of aging and may develop after repeated … with COPD
and may regulate the DNA damage response pathway that is linked to cellular senescence (70). …

… of senescent cells and describe the impact of these factors on tissue homeostasis. We also
summarize the cellular pathways… chronic inflammation might arise during aging. We discuss a …

… , the insulin/Akt pathway, and other metabolic pathways. Interestingly, most … aging also
regulate cellular senescence, suggesting a causative link between cellular senescence and aging…

… aging and disease once homeostasis of senescent cells is altered. … interplay between
pathways of DDR, senescence, and … of senescent cells in light of central senescence pathways. …

… First, I will analyze cellular senescence. The most noticeable feature of cell senescence is
cell … In this section I discuss the aging-promoting pathway in different species because, unlike …

… cells, can reinforce and propagate cellular senescence, by a process named secondary
senescence [… can activate p21/p53 downstream pathways to induce cellular senescence [14,25]. …