… Cellular senescence is a primary aging process and tumor suppressive mechanism …
mediate the cellular senescence phenotype through mechanisms that converge on pathways that …

… The quantity and quality of MSCs decline during aging, … senescence as a result of aging,
discuss the progress of research on mechanisms and signalling pathways of MSC senescence, …

… Another pro-survival pathway active in senescent cells is the PI3K/AKT pathway, which
can be targeted by dasatinib and quercetin. Dasatinib (D), an anticancer drug, is a tyrosine …

… In analogy to cancer cells, senescence cells activate the cGAS-STING pathway in response
… support the notion that cellular senescence and aging are part of a cellular interactome, but …

… cellular senescence in aging and age-related diseases. We also discuss the differential impact
of longevity interventions on senescence … signaling pathways impact on the rate of aging, …

… senescence pathways seen in human cells … cell senescence literature was that the in vivo
studies essential to testing the causal relationship between ageing and cellular senescence (…

… cellular senescence. In addition, substantial progress has been made in understanding some
of the root causes of aging … apoptosis and cellular senescence might impact the aging of …

… of aging, multi-modal and multi-perspective studies are important. The process and
accumulation of cellular senescence … Organ and organismal aging are often accompanied by the …

… by mutations in the Ras/Raf pathway) without any apparent loss of telomeric DNA [40].
While the existence of this pathway strengthens the evidence for senescence as an anti-tumour …

… Pathways to cellular senescence. This figure summarizes the different stressors (top layer)
and molecular mechanisms (top middle layer) involved in mediating each type of …