Stimulation of human and rat alveolar macrophages by urban air particulates: effects on oxidant radical generation and cytokine production

S Becker, JM Soukup, MI Gilmour, RB Devlin - Toxicology and applied …, 1996 - Elsevier
particulates. Supernatants of AM exposed to the indicated concentrations of UAP particles
particles collected from the ambient air may also contain mi- preparations used in this study …

Systemic inflammatory response induced by particulate matter air pollution: the importance of bone-marrow stimulation

SF Eeden, JC Hogg - … of Toxicology and Environmental Health, Part …, 2002 - Taylor & Francis
… We conclude that exposure to ambient particulate matter airstimulate the bone marrow
to release leukocytes and platelets. We postulate that this systemic response to particulate air

Phagocytosis of particulate air pollutants by human alveolar macrophages stimulates the bone marrow

H Mukae, JC Hogg, D English… - … of Physiology-Lung …, 2000 - journals.physiology.org
… In the present study, we used TNF-α as a marker of human AM stimulation and the rabbit
model to determine the collective effect of the AM-derived mediators on the bone marrow. A …

Cytokines Involved in the Systemic Inflammatory Response Induced by Exposure to Particulate Matter Air Pollutants (PM10)

SF van EEDEN, WC Tan, T Suwa, H Mukae… - American journal of …, 2001 - atsjournals.org
… Military recruits exposed to high concentrations of particulate matter air pollution during the
… with bone marrow stimulation (8). We postulate that atmospheric particles stimulate AM to …

Diesel exhaust particles stimulate human airway epithelial cells to produce cytokines relevant to airway inflammation in vitro

T Ohtoshi, H Takizawa, H Okazaki, S Kawasaki… - Journal of Allergy and …, 1998 - Elsevier
… Objective: We studied the effect of suspended particulate matter … colony-stimulating factor
(GM-CSF) by human airway epithelial … air pollutants, stimulated cytokine production by human

Regulation of cytokine production in human alveolar macrophages and airway epithelial cells in response to ambient air pollution particles: further mechanistic studies

S Becker, S Mundandhara, RB Devlin… - Toxicology and applied …, 2005 - Elsevier
stimulated previously unexposed and diesel exposed cells were the same. In contrast, AM
exposed to ambient air pollution particles … production by air ambient pollution particles, but not …

Effects of metals within ambient air particulate matter (PM) on human health

LC Chen, M Lippmann - Inhalation toxicology, 2009 - Taylor & Francis
… effects caused by inhalation of ambient air particulate matter (PM) containing metals, … )
human and laboratory animal exposures to concentrated ambient particles (CAPs), and (2) human

Differential particulate air pollution induced oxidant stress in human granulocytes, monocytes and alveolar macrophages

S Becker, JM Soukup, JE Gallagher - Toxicology in vitro, 2002 - Elsevier
… The data presented are derived from stimulation of 2×10 5 cells with 100 μg particles since
only a few of the dusts were reactive at the lower particle amounts (30 and 10 μg) As can be …

The effects of ambient particulate matter on human alveolar macrophage oxidative and inflammatory responses

K Sawyer, S Mundandhara, AJ Ghio… - Journal of Toxicology …, 2009 - Taylor & Francis
… Ambient air particles and DEP may suppress TNF-α release … human AM stimulated with
different signal transduction agonists was measured. Comparison across several known stimuli

Response of human alveolar macrophages to ultrafine, fine, and coarse urban air pollution particles

S Becker, JM Soukup, C Sioutas… - Experimental lung …, 2003 - Taylor & Francis
… of air pollution particles in stimulating inflammation has been emphasized both in animal
models and in human … with UF, fine, and coarse particles, collected simultaneously from 2 urban …