… of organoids that represent airway and alveolar … and alveolar cell types [88]. Recently, we
reported long-term culture conditions for adult human lung tissue-derived airway organoids [89]…

… human adult stem cell-derived organoid model representing the upper respiratory airways
and … We aimed to establish human airway organoids of bronchiolar and alveolar differentiation …

… of the respiratory system. We describe a defined protocol to derive human lung organoids from
adult … tract is lined with two distinct types of epitheliums, ie, airway epithelium and alveolar …

… adult human lung revealed subclusters enriched for adult stem cell signature (ASCS) genes.
We found that alveolar progenitors in organoid … organoids with both alveolar and bronchial …

… Thus, achieving a deeper understanding of the heterogeneity in AT2 cells is important for
deriving functional and mature AOs resembling human adult alveoli for disease modeling, drug …

… coglycolide (PLG) or polycaprolactone (PCL) allowed maturation to tube-like structures
that resembled the structure and cellular diversity of adult airways. Since PS cell-derived …

… We explored whether organoid expansion … Airway epithelial cells were obtained from tracheal
aspirates (TA) from preterm newborns and from bronchoalveolar lavage (BAL) or bronchial …

… are available [4–7], but in this review, we focus on organoid studies in the alveolar space, …
the regenerative function of AT2 cells in adult alveolar epithelia. Studies are still underway to …

… Establishment of airway organoids and tracheobronchospheres depends on the availability
of sufficient numbers of airway basal cells, which are the adult tissue-specific stem cells. We …

… human lung organoids, the same source for generating airway organoids as previously …
optimized 2D airway organoids from lung organoids, which mimic the airway epithelium more …