… in the resistance towards gemcitabine exhibited by the pancreatic cancer cell lines used
in this study, the effect of the specific Akt inhibitor LY294002 (Brunn et al., 1996; Sekulic et al., …

… , translation, and cell cycle regulation [46]. A great number of cancer cells with mutations
in the PI3K/AKT-mTOR pathway are susceptible to the cell growth blocking induced by …

… what was found in gene expression of PI3K/AKT/mTOR in these GC cell lines. As protein
expression was more intense in AGS cells, this cell line was treated with 50 nM rapamycin for …

… Heterogeneity is a common phenomenon of parental tumor cell lines, and highly metastatic
tumor cell variants pre-exist in parental tumor cell populations [7–9]. SKOV3 cells, which …

… We concluded that: 1) the PI3K-Akt pathway plays an important role in preventing … PI3K-Akt
pathway plays a critical role in regulating cell proliferation in human gastric carcinoma cells…

… Cells lines Four endometrial cancer cell lines were used in this study (Table 1). Two cell
lines were PTEN mutated and two were PTEN wild-type; all were previously purchased and …

… the three types of tumor cell lines tested in this study displayed such characteristics, this is
the first evidence showing negative effects of the constitutively active PI3K/Akt pathway on HIF …

… The cell lines included the following: PC9, which is EGFR TKI sensitive … PI3K/AKT and
MEK/ERK signal transduction pathways of EGFR on cell proliferation and apoptosis in cell lines …

… in ovarian cancer cells. Activation of the PI3K/Akt pathway is one of the critical steps in cell
… The activated Akt inhibits apoptosis by multiple mechanisms, including phosphorylation of …

… , we discuss PI3K/Akt pathway components and functions as well as its alteration in cancer
and … In pancreatic cancer cell lines, PI3K/Akt pathway has been found to be implicated in …