… ; a pro-apoptotic tumor suppressor protein) has been shown to be associated with cisplatin
resistance in pancreatic cancer cells through upregulation of Akt/PI3K signaling [33]. PI3K/Akt/…

… cells, it failed to significantly improve the outcome of pancreatic carcinoma patients. The …
PI3K/Akt in the resistance of five pancreatic carcinoma cell lines towards gemcitabine. Treatment …

… have provided strong evidence on the role of PI3K/AKT/mTOR pathway in PDAC, clinical …
PI3K/AKT/mTOR pathway could provide valuable assets for treatment of pancreatic cancer …

… are not involved in PI3K/Akt/mTOR hyperactivation in pancreatic cancer. PTEN loss mainly
… Treatment of Panc1 human pancreatic cancer cells with TGFβ1 for 12 h markedly reduced …

… Our findings indicated that scoparone inhibits pancreatic cancer cell proliferation, migration,
and invasion, and induced cell cycle arrest and apoptosis through the PI3K/Akt signaling …

… treating pancreatic cancer patients. In this review, we focus on PI3K/AKT/mTOR inhibitors that
have shown great anti-tumor … on xenograft models and pancreatic cell lines and inhibitors …

… of PI3K/Akt/mTOR and Shh pathways may be beneficial for the treatment of pancreatic
cancer. … In summary, our findings suggest that combined inhibition of PI3K/Akt/mTOR and Shh …

… of the PI3K/Akt pathway in pancreatic cancer cells as demonstrated by the reduction of the
Akt … Finally, α-mangostin significantly inhibited the growth of BxPc-3 tumor mouse xenografts. …

… activation of AKT and Uro A treatment significantly reduced SC79 … through an AKT-dependent
mechanism, we treated control or AKT … with IGF-1 treatment of AKT knockdown cells. Next, …

… Thus, our results reveal that LY294002 displays the opposite effect on PI3K-dependent AKT
… -resistant pancreatic cancer cells. We suggest that targeting the PI3K/AKT signaling pathway …