PNPLA3 gene polymorphism is associated with predisposition to and severity of alcoholic liver disease

H Salameh, E Raff, A Erwin, D Seth… - Official journal of the …, 2015 - journals.lww.com
… 3 (PNPLA3) gene and hepatic fat content ( 9 ). In addition, a strong association between
PNPLA3 genotype and elevated alanine aminotransferase levels as well as hepatic fat content …

[PDF][PDF] Genetic variation in the PNPLA3 gene is associated with alcoholic liver injury in caucasians

F Stickel, S Buch, K Lau, HM zu Schwabedissen… - …, 2011 - Wiley Online Library
… an association of the studied polymorphism, with alcohol intake itself unlikely. These results
… robust genotypic effect. Our data underscore the significance of genotype PNPLA3 rs738409…

[HTML][HTML] PNPLA3 as a genetic determinant of risk for and severity of non-alcoholic fatty liver disease spectrum

H Salameh, M Al Hanayneh, M Masadeh… - Journal of clinical and …, 2016 - ncbi.nlm.nih.gov
PNPLA3 rs738409 genotype frequency in the control populations included in this meta-analysis.
Expected genotype … between expected and observed genotype counts. Values < 3.84 …

Genetic variation in PNPLA3 but not APOC3 influences liver fat in non‐alcoholic fatty liver disease

J Hyysalo, I Stojkovic, A Kotronen… - Journal of …, 2012 - Wiley Online Library
… effects of genotypes on clinical variables and liver fat content. … by APOC3 and PNPLA3
genotypes was calculated using … liver fat while the variation at rs738409 in PNPLA3 accounted …

Association between PNPLA3 rs738409 polymorphism and nonalcoholic fatty liver disease: a systematic review and meta-analysis

N Salari, N Darvishi, K Mansouri, H Ghasemi… - BMC endocrine …, 2021 - Springer
… -analyze the association between PNPLA3 rs738409 polymorphism and non-alcoholic fatty
liver. … In this study, after investigating the association between different genotypes of PNPLA3

Genetic Variants in PNPLA3 and Risk of Non-Alcoholic Fatty Liver Disease in a Han Chinese Population

XE Peng, YL Wu, SW Lin, QQ Lu, ZJ Hu, X Lin - Plos one, 2012 - journals.plos.org
… However, the contribution of PNPLA3 rs738409 genotypes to … showed that the PNPLA3
rs738409 polymorphism was not … 1 to 2 risk genotypes), we found that the combined genotype

[HTML][HTML] PNPLA3 genetic variation in alcoholic steatosis and liver disease progression

F Stickel, J Hampe, E Trépo, C Datz… - … surgery and nutrition, 2015 - ncbi.nlm.nih.gov
… In addition, 744 healthy controls were also genotyped for PNPLA3 rs738409 to find the GG
genotype associated with cirrhosis with an OR of 2.71 (95% CI, 1.53-4.79). A similar finding …

PNPLA3 GG genotype and carotid atherosclerosis in patients with non-alcoholic fatty liver disease

S Petta, L Valenti, G Marchesini, V Di Marco, A Licata… - PloS one, 2013 - journals.plos.org
… to PNPLA3 genotype (A). Prevalence of carotid thickening according to age and to PNPLA3
genotype (B). … intima-media thickness values according to age and to PNPLA3 genotype (C). …

Distinct, alcohol-modulated effects of PNPLA3 genotype on progression of chronic hepatitis C

T Müller, S Buch, T Berg, J Hampe… - Journal of …, 2011 - journal-of-hepatology.eu
… Assuming a recessive model controlling for sex, age, BMI, and viral genotype 3, both the …
associated with genotype PNPLA3 rs738409 GG. Upon stratification of alcohol intake into …

PNPLA3 genotype and risk of liver and all‐cause mortality

S Stender, R Loomba - Hepatology, 2020 - journals.lww.com
… A subset of the cohort (n = 5,662) was genotyped for PNPLA3 p.I148M, a common variant
known to associate robustly with NAFL as well as NASH. The participants were followed for …