The NLRP3 inflammasome in non-alcoholic fatty liver disease and steatohepatitis: Therapeutic targets and treatment

L Yu, W Hong, S Lu, Y Li, Y Guan, X Weng… - Frontiers in …, 2022 - frontiersin.org
… Non-alcoholic fatty liver disease (NAFLD) is among the most … >5%) without significant alcohol
consumption. The incidence of … of NAFLD is non-alcoholic steatohepatitis (NASH), which …

The NLRP3 inflammasome in alcoholic and nonalcoholic steatohepatitis

J Knorr, A Wree, F Tacke… - Seminars in liver …, 2020 - thieme-connect.com
… domain containing 3 (NLRP3) inflammasome, a multiprotein complex that … approaches
targeting NLRP3 inflammasome and related … The incidence of alcoholic steatohepatitis (ASH) and …

Mitochondria and the NLRP3 inflammasome in alcoholic and nonalcoholic steatohepatitis

S Torres, P Segalés, C García-Ruiz… - Cells, 2022 - mdpi.com
… Mitochondrial damage and activation of inflammasome complexes have a role in
inducing … factors that activate the inflammasome complexes. NLRP3 inflammasome (nucleotide-binding …

Inflammasome activation in the liver: Focus on alcoholic and non-alcoholic steatohepatitis

G Szabo, A Iracheta-Vellve - Clinics and research in hepatology and …, 2015 - Elsevier
Inflammasome activation in alcoholic steatohepatitis. ATP and uric acid are released by …
In mice with MCD diet, we found TLR4, TLR9, AIM2, and NLRP3 inflammasome mRNA, and …

Interleukin‐1 and inflammasomes in alcoholic liver disease/acute alcoholic hepatitis and nonalcoholic fatty liver disease/nonalcoholic steatohepatitis

H Tilg, AR Moschen, G Szabo - Hepatology, 2016 - journals.lww.com
… , and gut integrity, contributing to their role in alcoholic steatohepatitis and NAFLD (Table 2).
… diet‐induced steatohepatitis. Both NLRP3 inflammasome activation and levels of NLRP3‐…

Liraglutide ameliorates non-alcoholic steatohepatitis by inhibiting NLRP3 inflammasome and pyroptosis activation via mitophagy

X Yu, M Hao, Y Liu, X Ma, W Lin, Q Xu, H Zhou… - European journal of …, 2019 - Elsevier
… accumulation, inhibited NLRP3 inflammasome and pyroptosis … that liraglutide suppresses
NLRP3 inflammasome-induced … that liraglutide suppresses NLRP3 inflammasome-induced …

A pharmacological inhibitor of NLRP3 inflammasome prevents non-alcoholic fatty liver disease in a mouse model induced by high fat diet

G Yang, HE Lee, JY Lee - Scientific reports, 2016 - nature.com
NLRP3) inflammasome is closely associated with the development and progression of
non-alcoholic fatty liver disease … mice by regulation of the NLRP3 inflammasome in the liver. Daily …

Sweroside prevents non-alcoholic steatohepatitis by suppressing activation of the NLRP3 inflammasome

G Yang, JH Jang, SW Kim, SH Han, KH Ma… - International Journal of …, 2020 - mdpi.com
NLRP3 inflammasome activation is associated with NASH pathology. We hypothesized that
suppressing the NLRP3 inflammasome could be … of the NLRP3 inflammasome and identified …

[PDF][PDF] Cardiolipin inhibitor ameliorates the non-alcoholic steatohepatitis through suppressing NLRP3 inflammasome activation.

J Liu, T Wang, K He, M Xu… - European Review for …, 2019 - europeanreview.org
… regulated the level of NLRP3 expression. Furthermore, we … the protein expressions of
CLS1, NLRP3, ASC, and Caspase… that the upregulation of NLRP3 inflammasome activated by …

Liraglutide protects non-alcoholic fatty liver disease via inhibiting NLRP3 inflammasome activation in a mouse model induced by high-fat diet

W Zhu, PP Feng, K He, SW Li, JP Gong - Biochemical and biophysical …, 2018 - Elsevier
… non-alcoholic fatty liver disease (NAFLD) in mice through inhibiting the NLRP3 inflammasome
in … The expressions of NLRP3 inflammasome components (including NLRP3, ASC, and …