… ‘(CYP11B2 or aldosterone synthase) and (gene or variants or polymorphism or … variant
and hypertension and related phenotypes such as plasma renin activity, plasma aldosterone, …

… aldosterone is not confined to these rare diseases. Relatively frequent polymorphisms of
the gene encoding the enzyme aldosterone synthase (… that a common gene variant, the C-344T …

… In summary, we have observed an association of -344T/C polymorphism of aldosterone
synthase gene with hypertension in case-control study in Caucasian subjects from Czech …

… Thus we provide evidence for involvement of variation in the aldosterone synthase gene in
… any role or mechanism whereby variation in the aldosterone synthase gene leads to disease. …

… have a raised aldosterone to renin ratio (ARR) suggesting that aldosterone production is …
activity of aldosterone synthase caused by genetic variation in the CYP11B2 gene. We …

… nonsense mutation and intron retention mutation were … levels of aldosterone indicated that
aldosterone synthase remained… the aldosterone synthesis catalyzed by the CYP11B2 gene in …

… or their regulatory regions could thus contribute to genetic variation in susceptibility to
essential hypertension. To test this hypothesis, we performed 2 complementary studies of the …

… To our knowledge, there has been no report of Chinese cases with confirmed genetic
analysis. Here, we describe a case of aldosterone synthase deficiency in a Chinese man and …

… Alongside monogenic forms of hypertension, a number of relatively common genetic
variants appear to be associated with higher blood pressure and increased susceptibility to …

… genetic analyses of the CYP11B2 gene from four patients suffering from aldosterone synthase
… 4173C > G mutation leads to the substitution of serine by arginine at amino acid position …