… Nevertheless, few RCTs have been carried out to compare the efficacy and safety of different
ALK inhibitors directly.9, 10 In the present study, we attempted to compare each ALKi by …

… with the use of ALK inhibitors. We … efficacy of ALK inhibitors compared to chemotherapy
(ALK vs. chemo) and 2nd generation ALK inhibitors compared to 1 st generation ALK inhibitors (…

… Clinicians should be aware of the new designation of safety … safety profile of each of those
agents we conducted a systematic review of prospective trials testing various ALK inhibitors (…

… ALK inhibition as a therapeutic strategy in ALK-rearranged NSCLC management, with a
focus on a specific ALK–… data about ALK inhibition as a therapeutic strategy in ALK-rearranged …

… variant are relatively small (particularly for variant 2), this study represents the largest analysis
of ALK inhibitor efficacy by ALK fusion variant type in the context of a prospective phase III …

… in safety between patients with different driver mutations. For patients with ALK mutations or
… with results for ALK inhibitors, especially second generation ALK inhibitors, was available for …

… This study reviews the pharmacodynamics, efficacy and safety of ALK‑TKI … ALK-TKIs exhibit
excellent clinical efficacy in ALK-positive NSCLC (11). In recent years, several ALK inhibitors …

… ALK can become increasingly complex in patients who have progressed on multiple lines of
ALK inhibitor … have the potential to affect alectinib treatment efficacy, having been previously …

… the efficacy and safety of alectinib, a highly selective, CNS-active ALK inhibitor, in ALK+
NSCLC … Methods: Eligible pts ( ≥ 18 yrs; locally advanced or metastatic ALK+ NSCLC [by FDA-…

… with ALK-positive NSCLC and no prior ALK inhibitor therapy … intolerable toxicity to investigate
the efficacy and safety. Results: As … with ALK-positive NSCLC but naïve to any ALK inhibitor …