… AGT synthesis, on blood pressure in hypertensive patients. … of ALN-AGT, we conducted a
multicenter study randomizing patients aged 18-65 years with mild to moderate hypertension (…

… , &26% of the adult population experiences hypertension, and … the United States adult
population is hypertensive, and one … of the angiotensinogen (AGT) gene with hypertension. We …

… Study showing that the increased risk of hypertension associated with the AGT TT genotype
is further elevated in the subjects carrying both the AGT TT and the ACE DD genotypes (6). …

… ALN-AGT01 were generally well-tolerated in patients with mild to moderate hypertension …
effect of ALN-AGT01 and potential durability of effect in lowering AGT beyond 3 months …

… of ALN-AGT, we conducted a multicenter study randomizing patients aged 18-65 years with
mild to moderate hypertension (… BP reduction in the general adult population. No adequately …

… the efficacy and safety of ALN-AGT01 as a monotherapy in adults with mild to moderate …
in serum angiotensinogen (AGT). The inclusion criteria are adult male or female subjects (18–75 …

… Global tests show that both genes are associated with hypertension. We did not find any
significant association between haplotype and hypertension status in either AGT or AGTR1. …

… Worldwide 1 in 3 adults are hypertensive. Although the treatment of hypertension
effectively … AGT siRNA in rats displaying hypertension and renal injury (SHR, DOCA-salt–treated …

… ’s association with risk of hypertension (using various … relating to AGT (AGT gene expression
and circulating AGT protein … that ALN-AGT01 leads to a more than 90% reduction in AGT …

… data about all adult patients with systolic BP > … AGT-siRNA dose effectively lowered MAP
to the same extent as the initial dose. In summary, AGT-RVR is a highly selective tool for AGT …