… and time as covariates for efficacy of the HIV vaccine regimen ALVAC-HIV (vCP1521) and AIDSVAX B/E: a post-hoc analysis of the Thai phase 3 efficacy trial RV 144

ML Robb, S Rerks-Ngarm, S Nitayaphan… - The Lancet infectious …, 2012 - thelancet.com
… “vaccine efficacy”, “HIV vaccine trial”, and “HIV vaccine clinical study” for HIV vaccine efficacy
… We did not identify any previous studies of HIV vaccines showing efficacy. There was no …

ALVAC-HIV B/C candidate HIV vaccine efficacy dependent on neutralization profile of challenge virus and adjuvant dose and type

L Schifanella, SW Barnett, M Bissa, V Galli… - PLoS …, 2019 - journals.plos.org
vaccine trial using the MF59 adjuvant rather than Alum with … the relative efficacy of identical
ALVAC-HIV B/C HIV vaccines with Alum … reason for the decreased vaccine efficacy, via lower …

Vaccine efficacy of ALVAC-HIV and bivalent subtype C gp120–MF59 in adults

GE Gray, LG Bekker, F Laher… - … England Journal of …, 2021 - Mass Medical Soc
… is essential to eradicating human immunodeficiency virus (HIV) infection. A canarypox–protein
HIV vaccine regimen (ALVAC-HIV plus AIDSVAX B/E) showed modest efficacy in …

Vaccination with ALVAC and AIDSVAX to prevent HIV-1 infection in Thailand

S Rerks-Ngarm, P Pitisuttithum… - … England Journal of …, 2009 - Mass Medical Soc
… Although our study provided preliminary evidence that an HIV vaccine regimen has the … :
vaccine efficacy may have decreased over the first year after vaccination, and vaccine efficacy

A tale of four studies: HIV vaccine immunogenicity and efficacy in clinical trials

S Zolla-Pazner, NL Michael, JH Kim - The Lancet HIV, 2021 - thelancet.com
… RV144 consisted of giving ALVAC at weeks 0 and 4, and then ALVAC and AIDSVAX at weeks
12 and 24. The study was done in Thailand and resulted in a vaccine efficacy of 31·2% (p=…

Analysis of V2 antibody responses induced in vaccinees in the ALVAC/AIDSVAX HIV-1 vaccine efficacy trial

S Zolla-Pazner, AC deCamp, T Cardozo… - PloS one, 2013 - journals.plos.org
… multiple HIVHIV vaccines that show efficacy, however, the results support continued dissection
of Ab responses to the V2 region which may illuminate mechanisms of protection from HIV

Subtype C ALVAC-HIV and bivalent subtype C gp120/MF59 HIV-1 vaccine in low-risk, HIV-uninfected, South African adults: a phase 1/2 trial

LG Bekker, Z Moodie, N Grunenberg, F Laher… - The lancet HIV, 2018 - thelancet.com
… Modest efficacy was reported for the HIV vaccine tested in the RV144 trial, … (ALVAC) and
envelope (env) glycoprotein (gp120). These vaccine components were adapted to express HIV-…

… evaluation of the virologic, immunologic, and clinical course of volunteers who acquired HIV-1 infection in a phase III vaccine trial of ALVAC-HIV and AIDSVAX B/E

S Rerks-Ngarm, RM Paris… - The Journal of …, 2013 - academic.oup.com
vaccine efficacy (VE P ) as the percent reduction (vaccine vs … should also be considered
in HIV vaccine trials and is part of … will provide further insight for HIV vaccine development. …

HIV vaccine efficacy and immune correlates of risk

RJ O'Connell, JL Excler - Current HIV research, 2013 - ingentaconnect.com
… regimens have reached Phase IIB or Phase III efficacy … put the efficacy and immunogenicity
results of HIV vaccine trials in … covariates for efficacy of the HIV vaccine regimen ALVAC-HIV (…

Comprehensive analysis of virus-specific T-cells provides clues for the failure of therapeutic immunization with ALVAC-HIV vaccine

L Papagno, G Alter, L Assoumou, RL Murphy, F Garcia… - Aids, 2011 - journals.lww.com
… of antiviral efficacy for protection against pathogenic organisms [23–25] . We speculated
that the ALVAC-HIV vaccine may have modulated the quality, rather than the quantity, of HIV-…