A vicious circle of alveolar macrophages and fibroblasts perpetuates pulmonary fibrosis via CCL18

A Prasse, DV Pechkovsky, GB Toews… - American journal of …, 2006 - atsjournals.org
lung fibroblasts partly mediated via CCL18. Conclusions: Our findings suggest that AMs from
patients with pulmonary fibrosis … loop with lung fibroblasts perpetuating fibrotic processes. …

Macrophages in lung fibrosis

T Ogawa, S Shichino, S Ueha… - International …, 2021 - academic.oup.com
Pulmonary fibrosis (PF) is a disease in which excessive … of fibroblasts lead to disruption of
the normal lung structure … could discriminate subsets of lung macrophages more specifically in …

Alveolar macrophages drive lung fibroblast function in cocultures of IPF and normal patient samples

CM Novak, S Sethuraman, KL Luikart… - … of Physiology-Lung …, 2023 - journals.physiology.org
… , a phagocytic immune cell, are found in the alveolar space and in the interstitium of the
lung… into lung macrophages following injury or insult such as during pulmonary fibrosis. The …

Mechanisms of pulmonary fibrosis. Spontaneous release of the alveolar macrophage-derived growth factor in the interstitial lung disorders.

PB Bitterman, S Adelberg… - The Journal of clinical …, 1983 - Am Soc Clin Investig
fibroblast proliferation found in the alveolar walls of these patients.In this regard, the present
study was designed to determine whether alveolar macrophages … factor for fibroblasts. The …

[HTML][HTML] S100a4 is secreted by alternatively activated alveolar macrophages and promotes activation of lung fibroblasts in pulmonary fibrosis

W Zhang, S Ohno, B Steer, CA Staab-Weijnitz… - Frontiers in …, 2018 - frontiersin.org
macrophages are an important cellular source of S100a4. Thus, we hypothesized that also
in pulmonary fibrosis, M2 macrophages … proliferation and activation of fibroblasts. To prove …

[HTML][HTML] Macrophages in lung injury, repair, and fibrosis

P Cheng, S Li, H Chen - Cells, 2021 - mdpi.com
… differentiation of lung fibroblasts, persistent alveolar injury … the role of macrophage polarization
in the pulmonary fibroticAlveolar macrophages account for 55% of lung immune cells …

Activation of alveolar macrophages via the alternative pathway in herpesvirus-induced lung fibrosis

AL Mora, E Torres-González, M Rojas… - American journal of …, 2006 - atsjournals.org
pulmonary fibrosis by infecting IFN-γR–deficient mice (IFN-γR −/− ) with the murine γ-herpesvirus
68. Because alveolar macrophages … activation of macrophages and/or fibroblasts as an …

Exaggerated spontaneous release of platelet-derived growth factor by alveolar macrophages from patients with idiopathic pulmonary fibrosis

Y Martinet, WN Rom, GR Grotendorst… - … England Journal of …, 1987 - Mass Medical Soc
… normal fibroblasts into continuously proliferating cells in vitro, recent studies have shown
that activated blood monocytes, in vitro matured monocytes, and alveolar macrophages all …

A spatially restricted fibrotic niche in pulmonary fibrosis is sustained by M-CSF/M-CSFR signalling in monocyte-derived alveolar macrophages

N Joshi, S Watanabe, R Verma… - European …, 2020 - Eur Respiratory Soc
… in physical proximity to areas of fibrosis (macrophages, fibroblasts and alveolar type II cells)
… -induced pulmonary fibrosis: monocyte-derived alveolar macrophages and Retnla + alveolar

Alveolar macrophage stimulation of lung fibroblast growth in asbestos-induced pulmonary fibrosis.

I Lemaire, H Beaudoin, S Masse… - The American journal of …, 1986 - ncbi.nlm.nih.gov
… (s) for lung fibroblasts. Because pulmonary fibrosis may result from an increased number …
collagen-producing cells, we investigated the interactions between alveolar macrophages