… major groups of disabling lung diseases, chronic pulmonary fibrosis and emphysema. Such
… principle by the dying macrophage is thought to stimulate the fibroblast directly (40). Since …

… Staining for SDF-1/CXCL12 was also observed in endothelial cells and some alveolar
macrophages. Weak or no staining was noticed in the fairly normal areas of the IPF lungs. SDF1/…

… pulmonary fibrosis is thought to involve fibroblast stimulation by a product of alveolar
macrophages (… Macrophage-fibroblast interactions are now studied using an homologous system …

… Mechanistic studies suggest the alveolar macrophage (AM) plays an important role in the …
of alveolar macrophage-driven fibroblast proliferation by alternative macrophage mediators. …

… of tranilast on alveolar macrophage (AM) activation and on the development of fibrosis in
ICR … from AM up-regulate fibroblast proliferation and collagen production during the course of …

… pulmonary alveolar macrophages in terms of their recruitment and functional response. In
many models of fibrosis, macrophages … that lung macrophages caused cultured fibroblasts to …

… of IL-8 transcripts by alveolar macrophages from normal healthy volunteers … alveolar
macrophages was found to be significantly elevated in individuals with lone IPF or with lung fibrosis …

… macrophages, and later investigated in lung fibrosis, particularly idiopathic pulmonary fibrosis
… occur initially, producing organized alveolar exudates with fibroblasts proliferating and the …

… data), we found that ALI/ARDS alveolar fibroblasts had proliferation and collagen 1 secretion
… A vicious circle of alveolar macrophages and fibroblasts perpetuates pulmonary fibrosis via …

… injuries, characterized by fibroblast/myofibroblast expansion and abnormal accumulation
of … lung fibrosis using transgenic mice expressing human MMP9 in alveolar macrophages (…