Airway organoids as models of human disease

J van der Vaart, H Clevers - Journal of internal medicine, 2021 - Wiley Online Library
… the development of organoids that represent airway and alveolar epithelium. In this review,
we discuss these new tools and other recent advances in developing models for human lung …

Induction of alveolar and bronchiolar phenotypes in human lung organoids

L Hoareau, AST Engelsen, M Aanerud… - Physiological …, 2021 - Wiley Online Library
… derive a single human lung biopsy towards both alveolar and bronchiolar organoids. By
modulating … three different airway organoid subtypes from a distal lung biopsy: alveolar, broncho-…

A simple method to generate human airway epithelial organoids with externally orientated apical membranes

CA Boecking, P Walentek, LT Zlock… - … of Physiology-Lung …, 2022 - journals.physiology.org
… (23) sought to produce nasal, bronchial, and tracheal organoid cell models starting from
pluripotent cells obtained from human airway tissues. These organoid cell models included …

Airway and alveoli organoids as valuable research tools in COVID-19

M De Oliveira, MT De Sibio, FAS Costa… - ACS Biomaterials …, 2021 - ACS Publications
… to develop human airway organoids are listed and briefly described, and they include models
that replicate alveoli in specific and distal airways, and also the proximal airway; in addition…

[HTML][HTML] Human Airway and Alveolar Organoids from Bronchoalveolar Lavage Fluid

MY Liu, B Chen, M Borji… - American Journal of …, 2024 - atsjournals.org
airway organoids from a variety of human BAL samples and show that these organoids contain
diverse airway … of BAL-derived alveolar organoids. These techniques significantly expand …

Long‐term expanding human airway organoids for disease modeling

N Sachs, A Papaspyropoulos… - The EMBO …, 2019 - embopress.org
human airway organoids from broncho-alveolar resections or lavage material. The
pseudostratified airway organoids … We conclude that human airway organoids represent versatile …

[HTML][HTML] Human alveolar progenitors generate dual lineage bronchioalveolar organoids

K Hoffmann, B Obermayer, K Hönzke… - Communications …, 2022 - nature.com
… Importantly, we show that HTII-280 + progenitors have the potency to generate organoids
with both alveolar and bronchial cell types. In vitro induction and maintenance of an AT2 …

Establishing human lung organoids and proximal differentiation to generate mature airway organoids

C Li, MC Chiu, Y Yu, X Liu, D Xiao, J Huang… - JoVE (Journal of …, 2022 - jove.com
organoid model of the human airway epithelium. The long-term expansion of lung organoids
and differentiated airway organoids … , ie, airway epithelium and alveolar epithelium. The …

Alveolar wars: the rise of in vitro models to understand human lung alveolar maintenance, regeneration, and disease

KV Evans, JH Lee - Stem cells translational medicine, 2020 - academic.oup.com
… For functional analysis of alveolar cells, in vitro human alveolar organoids established from
… models containing alveolar cell types are severely lagging behind their airway counterparts. …

[HTML][HTML] Human organotypic airway and lung organoid cells of bronchiolar and alveolar differentiation are permissive to infection by influenza and SARS-CoV-2 …

CT Ekanger, F Zhou, D Bohan, ML Lotsberg… - Frontiers in cellular …, 2022 - frontiersin.org
Human Airway Organoids of Bronchiolar and Alveolar Differentiation We aimed to establish
human airway organoids of bronchiolar and alveolar … The organoid tissues were supplied …