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Influence of Mesenchymal and Biophysical Components on Distal Lung Organoid Differentiation

O Goltsis, C Bilodeau, J Wang, D Luo, M Asgari… - 2024 - researchsquare.com
22 天前 - … human pathology for identifying causal pathways and testing novel compounds.
Alveolar organoids derived from human … platforms for studying distal airway diseases like BPD, …
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Therapeutic Targeting of Aberrant Transitional Epithelial Cells in Lung Fibrosis Through NOX4 Inhibition

B Deskin, N Smith, J Manges… - B29. BIOMARKERS AND …, 2024 - atsjournals.org
95 天前 - … cells is essential for restoring the alveolar epithelium. Recent single cell RNA …
Organoid culture systems of human alveolospheres as well as donor-derived human small airway …
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Developing a Novel Therapeutic for Smokers Infected With SARS-CoV-2

KN Castillo, M Ghannam, T Rickabaugh… - … AND COVID-19 …, 2024 - atsjournals.org
95 天前 - … Methods: We exposed human alveolar type II (AT II) cells grown in organoids
and air-… -CoV-2 infection in primary human airway and alveolar lung cultures and the K18-ACE2 …
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Epithelial HIF Activation Impairs Distal Airway Derived Alveolar Repair

AS Mccall, M Chapman, E Krystofiak… - … THE PATHWAYS OF …, 2024 - atsjournals.org
95 天前 - … alveolar repair following injury is not well understood. METHODS: Human alveolar
organoids were … RESULTS: scRNA-seq of human alveolar organoids demonstrated that HIF …
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Human Induced Pluripotent Stem Cell-derived Lung Epithelial Cells in Micro-patterned Culture Distinguish SARS-COV-2 Variant Strains

S Gotoh, A Masui, R Hashimoto… - A71. CUTTING EDGE …, 2024 - atsjournals.org
95 天前 - … human lung cells and we can test various donor-derived iPSCs. However, the
conventional organoid … and differentiated them into alveolar or airway epithelial cells using each …
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Perinatal Obesity Induces Premature Alveolar Aging by AT2 Cell Depletion Via IL-6-driven Transcriptional Stress and Genome Instability

J Selle, O Klymenko, B Abend, T Trojan… - B28. LUNGS …, 2024 - atsjournals.org
95 天前 - … We recently demonstrated that perinatal obesity triggers bronchial and vascular …
genomic instability in alveolar epithelial cells type 2 (AT2) leading to alveolar simplification and …
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Idiopathic Pulmonary Fibrosis Alveolar Epithelial Type 2 Cells Are a Putative Cell of Origin for Basal-Like Cells in Distal Lung

A Berhan, B Scott, A Castaldi… - … : KEY CULPRITS IN …, 2024 - atsjournals.org
95 天前 - … Methods: AEC2s were isolated from cryopreserved IPF and normal human lungs …
organoid culture: 1) co-culture with MRC-5 human embryonic lung fibroblasts in small airway …
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Polyvinylchloride and Polypropylene Microparticles Affect Outgrowth of Murine Lung Organoids

GF Vasse, S Song, MH de Jager… - B57. MECHANISTIC …, 2024 - atsjournals.org
95 天前 - … murine airway and alveolar organoids. METHODS Developing murine airway and
alveolar organoids … After 14 days, the number and size of alveolar and airway organoids were …
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Muc5b Suppresses Alveolar Regeneration by Club Cells in COPD

Y Hu, N Liu, J Needell, M Koenigshoff… - … PATHOGENESIS OF A …, 2024 - atsjournals.org
95 天前 - … airway club cells adjacent to damaged alveoli. Further, we identified impaired alveolar
repair … Lastly, organoid assays demonstrated enhanced alveolar differentiation of Muc5b …
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Mitochondrial Adenine Nucleotide Translocase 2 (ANT2) Increases Alveolar Epithelial Cell Susceptibility to Ferroptosis in COPD

U Mbaekwe, J Shi, J Sui, N Oury, Q Hu… - … THE PANDORA BOX, 2024 - atsjournals.org
95 天前 - … in alveolar type II cells (ATIIs) from COPD patients. Loss of ANT2 in human bronchial
… Ant2-null ATII cells have reduced organoid forming capacity in a 3D alveolar organoid …
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