Investigation of Epithelial Cell Fate Decisions in the Developing Human Lung Guides the Generation of Human Lung Organoid Model Systems
A Miller - 2019 - deepblue.lib.umich.edu
… Each alveolar sac also possesses alveolar epithelial type II cells (AECII) that secrete
surfactant proteins to reduce surface tension, preventing airway collapse during exhalation. …
surfactant proteins to reduce surface tension, preventing airway collapse during exhalation. …
[HTML][HTML] RSV-induced changes in a 3-dimensional organoid model of human fetal lungs
TJ Harford, F Rezaee, BR Dye, J Fan, JR Spence… - PLoS …, 2022 - journals.plos.org
… In mature human [1] and murine [2] airways RSV shows elective tropism for ciliated cells
and alveolar epithelial cells. However, in HLOs, the present data suggest that RSV infectivity …
and alveolar epithelial cells. However, in HLOs, the present data suggest that RSV infectivity …
[HTML][HTML] ACE2 expression in organotypic human airway epithelial cultures and airway biopsies
Q Chen, S Langenbach, M Li, YC Xia, X Gao… - Frontiers in …, 2022 - frontiersin.org
… The A549 type II alveolar epithelial carcinoma cell line and BEAS-2B simian virus 40 (SV40)…
airway cell lines, ALI, and airway organoid culture to freshly isolated human bronchial …
airway cell lines, ALI, and airway organoid culture to freshly isolated human bronchial …
[PDF][PDF] Alveolus Lung-Chip cultures of patient-derived primary alveolar type-2 cells
S van Riet… - an.(2021 … - scholarlypublications …
… Although we obtained a pure alveolar organoid culture upon passaging of the organoids, …
for culture of small airway epithelial organoids and alveolar organoids from the same donor, …
for culture of small airway epithelial organoids and alveolar organoids from the same donor, …
[HTML][HTML] Human Lung Organoids—A Novel Experimental and Precision Medicine Approach
L Kühl, P Graichen, N von Daacke, A Mende… - Cells, 2023 - mdpi.com
… Lung organoids can be divided into different categories … alveolar organoids, bronchial
organoids, bronchioalveolar … In contrast, alveolar organoids resemble the structure of alveoli and …
organoids, bronchioalveolar … In contrast, alveolar organoids resemble the structure of alveoli and …
[HTML][HTML] Adult stem cell-derived complete lung organoid models emulate lung disease in COVID-19
C Tindle, MK Fuller, A Fonseca, S Taheri… - Elife, 2021 - elifesciences.org
… model that is complete with both proximal and distal airway epithelia. Monolayers derived
from adult lung organoids (ALOs), primary airway cells, or hiPSC-derived alveolar type II (AT2) …
from adult lung organoids (ALOs), primary airway cells, or hiPSC-derived alveolar type II (AT2) …
[HTML][HTML] Human airway organoids and microplastic fibers: A new exposure model for emerging contaminants
AS Winkler, A Cherubini, F Rusconi, N Santo… - Environment …, 2022 - Elsevier
… the inclusion of fibers in the organoid. This effect could … human airway organoids proved
suitability of the model for studying the effects of airborne microplastic contamination on humans …
suitability of the model for studying the effects of airborne microplastic contamination on humans …
[HTML][HTML] Human embryonic lung epithelial tips are multipotent progenitors that can be expanded in vitro as long-term self-renewing organoids
MZ Nikolić, O Caritg, Q Jeng, JA Johnson, D Sun… - elife, 2017 - elifesciences.org
… Our human tip organoids can be directed to differentiate towards alveolar or bronchiolar fate
… We confirmed that HTII-280 was not in the larger airways (Figure 1B, arrowhead), but it was …
… We confirmed that HTII-280 was not in the larger airways (Figure 1B, arrowhead), but it was …
Defining signals that promote human alveolar type I differentiation
Y Li, YS Prakash, Q Tan… - American Journal of …, 2024 - journals.physiology.org
… ATII versus promote ATI fates in 3D organoid cultures, and developed a human alveolar …
modest but not significant elevation in the percentage of CDKN1A+ cells in alveolar organoids …
modest but not significant elevation in the percentage of CDKN1A+ cells in alveolar organoids …
The use of human iPSC‐derived alveolar organoids to explore SARS‐CoV‐2 variant infections and host responses
C Gandikota, K Vaddadi, P Sivasami… - Journal of Medical …, 2024 - Wiley Online Library
… organoids derived from human embryonic stem cell (hESC) 15, 16 and bipotential airway
and alveolar organoids … to characterize human iPSCs (hiPSCs) derived alveolar organoids (…
and alveolar organoids … to characterize human iPSCs (hiPSCs) derived alveolar organoids (…