Investigation of Epithelial Cell Fate Decisions in the Developing Human Lung Guides the Generation of Human Lung Organoid Model Systems

A Miller - 2019 - deepblue.lib.umich.edu
… Each alveolar sac also possesses alveolar epithelial type II cells (AECII) that secrete
surfactant proteins to reduce surface tension, preventing airway collapse during exhalation. …

[HTML][HTML] RSV-induced changes in a 3-dimensional organoid model of human fetal lungs

TJ Harford, F Rezaee, BR Dye, J Fan, JR Spence… - PLoS …, 2022 - journals.plos.org
… In mature human [1] and murine [2] airways RSV shows elective tropism for ciliated cells
and alveolar epithelial cells. However, in HLOs, the present data suggest that RSV infectivity …

[HTML][HTML] ACE2 expression in organotypic human airway epithelial cultures and airway biopsies

Q Chen, S Langenbach, M Li, YC Xia, X Gao… - Frontiers in …, 2022 - frontiersin.org
… The A549 type II alveolar epithelial carcinoma cell line and BEAS-2B simian virus 40 (SV40)…
airway cell lines, ALI, and airway organoid culture to freshly isolated human bronchial

[PDF][PDF] Alveolus Lung-Chip cultures of patient-derived primary alveolar type-2 cells

S van Riet… - an.(2021 … - scholarlypublications …
… Although we obtained a pure alveolar organoid culture upon passaging of the organoids, …
for culture of small airway epithelial organoids and alveolar organoids from the same donor, …

[HTML][HTML] Human Lung Organoids—A Novel Experimental and Precision Medicine Approach

L Kühl, P Graichen, N von Daacke, A Mende… - Cells, 2023 - mdpi.com
… Lung organoids can be divided into different categories … alveolar organoids, bronchial
organoids, bronchioalveolar … In contrast, alveolar organoids resemble the structure of alveoli and …

[HTML][HTML] Adult stem cell-derived complete lung organoid models emulate lung disease in COVID-19

C Tindle, MK Fuller, A Fonseca, S Taheri… - Elife, 2021 - elifesciences.org
… model that is complete with both proximal and distal airway epithelia. Monolayers derived
from adult lung organoids (ALOs), primary airway cells, or hiPSC-derived alveolar type II (AT2) …

[HTML][HTML] Human airway organoids and microplastic fibers: A new exposure model for emerging contaminants

AS Winkler, A Cherubini, F Rusconi, N Santo… - Environment …, 2022 - Elsevier
… the inclusion of fibers in the organoid. This effect could … human airway organoids proved
suitability of the model for studying the effects of airborne microplastic contamination on humans

[HTML][HTML] Human embryonic lung epithelial tips are multipotent progenitors that can be expanded in vitro as long-term self-renewing organoids

MZ Nikolić, O Caritg, Q Jeng, JA Johnson, D Sun… - elife, 2017 - elifesciences.org
… Our human tip organoids can be directed to differentiate towards alveolar or bronchiolar fate
… We confirmed that HTII-280 was not in the larger airways (Figure 1B, arrowhead), but it was …

Defining signals that promote human alveolar type I differentiation

Y Li, YS Prakash, Q Tan… - American Journal of …, 2024 - journals.physiology.org
… ATII versus promote ATI fates in 3D organoid cultures, and developed a human alveolar
modest but not significant elevation in the percentage of CDKN1A+ cells in alveolar organoids

The use of human iPSC‐derived alveolar organoids to explore SARS‐CoV‐2 variant infections and host responses

C Gandikota, K Vaddadi, P Sivasami… - Journal of Medical …, 2024 - Wiley Online Library
organoids derived from human embryonic stem cell (hESC) 15, 16 and bipotential airway
and alveolar organoids … to characterize human iPSCs (hiPSCs) derived alveolar organoids (…