Alzheimer's disease: βamyloid plaque formation in human brain

P Seeman, N Seeman - Synapse, 2011 - Wiley Online Library
… of Alzheimer's disease is not known, the β-amyloid peptide … amino acids are suspected to
contribute to the disease. The … Alzheimer's disease effectively elevated β-amyloid-40 and β-…

Alzheimer's disease: βAmyloid protein and tau

M Morishima‐Kawashima… - Journal of neuroscience …, 2002 - Wiley Online Library
Research on the molecular pathogenesis of Alzheimer's disease (AD) has made great
strides over the last decade. This progress is the result of protein chemical analysis of two …

[HTML][HTML] Alzheimer's disease, β-amyloid protein and zinc

X Huang, MP Cuajungco, CS Atwood, RD Moir… - The Journal of …, 2000 - Elsevier
Alzheimer's disease (AD) is characterized by amyloid deposits within the neocortical parenchyma
and the cerebrovasculature. The main component of these predominantly extracellular …

Alzheimer's disease β-amyloid peptides are released in association with exosomes

L Rajendran, M Honsho, TR Zahn… - Proceedings of the …, 2006 - National Acad Sciences
… of Alzheimer's disease (AD) is a topic of debate, the consensus is that the accumulation of
β-amyloid (Aβ) … of the disease. The Aβ peptide is formed by the amyloidogenic cleavage of the …

Role of the βamyloid protein in Alzheimer's disease

SS Sisodia, DL Price - The FASEB Journal, 1995 - Wiley Online Library
… of Alzheimer's disease (AD) is the presence of amyloid … The principal component of amyloid
is the βamyloid protein (… and the extracellular domain of the amyloid precursor protein (APP)…

β-amyloid and the pathogenesis of Alzheimer's disease

BA Yankner, MM Mesulam - New England Journal of Medicine, 1991 - Mass Medical Soc
… meningovascular accumulation of β-amyloid in Alzheimer's disease. An … of β-amyloid
immunoreactivity in skin, intestine, and adrenal medulla in patients with Alzheimer's disease, …

Amyloid beta amyloidosis in Alzheimer's disease

DL Price, SS Sisodia, SE Gandy - Current opinion in neurology, 1995 - journals.lww.com
… The presence of amyloid deposits in the parenchyma of the amygdala, hippocampus, and …
hallmark of Alzheimer's disease. The principal component of amyloid is amyloid beta, a 39–43 …

Key factors in Alzheimer's disease: βamyloid precursor protein processing, metabolism and intraneuronal transport

TA Bayer, O Wirths, K Majtényi, T Hartmann… - Brain …, 2001 - Wiley Online Library
βamyloid (Aβ) component of senile plaques may be the key molecule in the pathology of
Alzheimer's disease … the βamyloid peptide is the predominantly neuronal βamyloid precursor …

Thioflavine T interaction with synthetic Alzheimer's disease βamyloid peptides: Detection of amyloid aggregation in solution

H Levine III - Protein Science, 1993 - Wiley Online Library
Thioflavine T (ThT) associates rapidly with aggregated fibrils of the synthetic β/A4‐derived
peptides β(1–28) and β(1–40), giving rise to a new excitation (ex) (absorption) maximum at …

Simvastatin strongly reduces levels of Alzheimer's disease β-amyloid peptides Aβ42 and Aβ40 in vitro and in vivo

K Faßbender, M Simons, C Bergmann… - Proceedings of the …, 2001 - National Acad Sciences
Recent epidemiological studies show a strong reduction in the incidence of Alzheimer's disease
in patients treated with cholesterol-lowering statins. Moreover, elevated Aβ42 levels and …