… γ-secretase as well as identifying transiently binding γ-secretase modulatory proteins have
been of great interest. In this review, decades of findings on γ-secretase in AD are discussed. …

… the pathogenesis of Alzheimer's disease (AD), and this peptide is cut out of the amyloid β-protein
precursor (APP) by the sequential action of β- and γ-secretases. γ-Secretase is a …

… of disease-modifying agents that target γ-secretase activity to lower levels of Aβ42 production
without blocking the overall processing of γ-secretase substrates. γ-Secretase modulators (…

… the discovery of the γ-secretase components, the biological functions of γ-secretase, as well
… , the role of γ-secretase in disease (especially in AD), and the current status and direction of …

Investigations into the proteolytic processing of amyloid precursor protein (APP) have
provided insights into both the pathogenesis of Alzheimer's disease and an unusual form of …

… γ-secretase complex is therefore believed to be critical in the pathogenesis of Alzheimer's
disease… degree of γ-secretase complex activity; these include γ-secretase complex assembly …

… ), followed by a second cleavage by γ-secretase. γ Secretase is a multimeric enzyme complex
… The cleavage by γ-secretase at several sites results in Aβ peptides of various lengths, with …

Alzheimer's disease (AD) is characterized pathologically by the abundance of senile
plaques and neurofibrillary tangles in the brain. We synthesized over 1200 novel gamma-secretase …

… Intramembrane proteolysis by the γ-secretase complex is important during development
and in the pathology of Alzheimer's disease. γ-Secretase has usually been considered as a …

… other γ-secretase substrates, especially Notch, which is essential for normal biological functions
3 , 4 . Here we report the discovery of a novel γ-secretase … with both γ-secretase and its …