… of membrane-bound CD40 with its cognate ligand, CD40 ligand (CD40L), as well as … forms
of CD40 (sCD40) and CD40L (sCD40L). Here, we review the role of this inflammatory dyad in …

… , being the most sensitive cell type to respond to CD40 ligand). Interaction between … of
CD40 ligand in Alzheimer's disease and in animal models of Alzheimer's disease and …

… studies on the role of CD40 and CD40L interactions in EAE and … target this dyad to combat
neuroinflammatory diseases. … other neurodegenerative disorders like Alzheimer’s Disease (15…

… of the CD40-CD40L interaction in promoting microglial activation induced by Alzheimer's
β-… This pro-inflammatory microglial response is deleterious in vitro, as CD40L and amyloid-β …

… CD40–CD40L dyad has also been implicated in other immune diseases including acute
or chronic graft-versus-host disease… More recently, the CD40–CD40L interaction has been …

… causes neurologic disease. Previously, we detected high levels of soluble CD40 ligand (CD40L) …
We now show that CD40, a receptor for CD40L, is highly expressed in brain endothelial …

… The CD40 receptor and CD40L ligand are transmembrane … The CD40 dyad was first
identified for its role in B-cell activation … of CD40 signaling in traumatic brain injury, Alzheimer’s …

… CD40L is enhanced in patients with Alzheimer's disease and independently associated with
the severity and progression of the disease. … role in AD for soluble CD40L, which might also …

… CD40 and CD40L are members of the tumor necrosis factor superfamily [8], [9]. It is now widely
accepted that the CD40–CD40L dyad … possible differential markers of Alzheimer disease …

… We investigated the plasma levels of soluble CD40 (sCD40) and the soluble CD40 ligand
(sCD40L) at baseline in 136 subjects with mild cognitive impairment (MCI) and 30 age-…