An essential feature of Alzheimer's disease (AD) is the accumulation of amyloid-β (Aβ)
peptides in the brain, many years to decades before the onset of overt cognitive symptoms. We …

… a primary role for amyloid-in Alzheimer's disease, treatment strategies targeted at
reducing … be sufficient to treat Alzheimer's disease. Instead, a broad outlook on neural-circuit-damaging …

… activity as a marker of neuronal functional activity, we found … cytochrome oxidase activity in
Alzheimer's disease brain may be … structurally intact in Alzheimer's disease may nonetheless …

… Here, we have summarized the major experimental approaches for neural circuit tracing
and their functional manipulations. Furthermore, the introduction of aberrant neural circuits …

… , such as Alzheimer's disease (AD), remains the underlying, disease-specific neuronal … in
the brain, neuronal dysfunction necessarily disrupts neuronal circuits. In this article, we review …

… Our findings that benzodiazepines restore neuronal circuit function and ameliorate memory
… doses of these drugs can in fact impair memory functions 44 and perhaps increase the risk of …

… Using CRACK, brain-wide projections of identified cells along with their behaviorally-defined
tuning properties were recently integrated to build a model of specific circuit functions [123]. …

… to the functional compromise observed in AD, We analyzed the glutamate receptor profile of
… circuits in young and aged monkeys as well as neurofilaments, to determine whether circuit-…

… Interneuron dysfunction may be a key pathological event in models of Alzheimer's disease
that represents a common mechanism of short-term memory loss; our observations of …

… on 1) circuit dysfunction in Alzheimer’s disease and 2) DBS for Alzheimer’s disease. Human
… DBS has the potential to restore circuit dysfunction in Alzheimer’s disease, similarly to other …