… Large amounts of money have been invested in AD research and drug development, yet …
stage drug candidates failing to meet primary measures of efficacy [Citation5]. Drug discovery in …

… To accomplish its mission of drug discovery for AD, the ISOA has forged a unique alliance
… scientists committed to accelerating drug discovery for AD. Combined, these scientists …

In this work, we review and comment upon the challenges and the ‘quo vadis’ in Alzheimer's
disease drug discovery at the beginning of the new millennium. We emphasize recent …

… management of our scientific resources or in the orientation of our research activity. The …
disease management; (v) a reorientation of drug discovery programs based on consensual drug …

… scientists are needed to operate core facilities for drug … barriers to drug discovery in academia
are generic problems in … to facilitating drug discovery and development should be disease …

… an interest in Alzheimer’s disease drug discovery research, have … It is exciting to see how
the drug discovery research has … developed by academic drug discovery scientists and early …

… been based on scientific principles of disease research or the realities of drug development,
it … endeavor to find innovative ways to develop drugs to successfully achieve the 2025 goal. …

… drug discovery and development. Our aim is to help scientists whose research may be relevant
to drug discovery … in patients with a disease such as Alzheimer's disease (AD). Here, we …

… , and National Center for Advancing Translational Science all fund aspects of research in
AD drug development. Non-National Institutes of Health federal funding comes from the …

… to the AD/ADRD drug development pipeline through collaborative … chemists, and computational
scientists. AI and open data … risk of Alzheimer's disease into mechanistic insight and drug …