Current and emerging avenues for Alzheimer's disease drug targets
R Loera‐Valencia, A Cedazo‐Minguez… - Journal of internal …, 2019 - Wiley Online Library
… This review summarizes pioneering efforts in mechanisms of disease and novel drug
targets for Alzheimer′s disease research. We would like to emphasize the importance of …
targets for Alzheimer′s disease research. We would like to emphasize the importance of …
Current drug targets for Alzheimer's disease treatment
… disease (source: Alzheimer’s Association, Chicago). We will briefly review the current state of
knowledge in Alzheimer’… to the development of new potential drug targets for AD treatment. …
knowledge in Alzheimer’… to the development of new potential drug targets for AD treatment. …
Novel drug targets based on metallobiology of Alzheimer's disease
… , and acts as catalyst for Aβ aggregation in Alzheimer's disease (AD). Thus, disruption of
aberrant … promise as a rational therapeutic strategy against Alzheimer's amyloid pathogenesis. …
aberrant … promise as a rational therapeutic strategy against Alzheimer's amyloid pathogenesis. …
A critical analysis of new molecular targets and strategies for drug developments in Alzheimer's disease
DK Lahiri, MR Farlow, K Sambamurti… - … drug targets, 2003 - ingentaconnect.com
… the basis for devising better drug targets, strategies for diagnosis, prevention and treatment.
… Overall, this current research should lead to the development of new potential drug targets …
… Overall, this current research should lead to the development of new potential drug targets …
Identification of novel drug targets for Alzheimer's disease by integrating genetics and proteomes from brain and blood
YN Ou, YX Yang, YT Deng, C Zhang, H Hu, BS Wu… - Molecular …, 2021 - nature.com
… Accordingly, we sought to discover promising drug targets for AD by combining high-throughput
proteomics in the brain and blood with genetic data to determine the genomic …
proteomics in the brain and blood with genetic data to determine the genomic …
Current status of drug targets and emerging therapeutic strategies in the management of Alzheimer's disease
S Ghosh, S Durgvanshi, S Agarwal… - Current …, 2020 - ingentaconnect.com
Alzheimer’s disease (AD) is a chronic neurodegenerative disease affecting the elderly. AD is
associated with a progressive decline in memory and cognitive abilities, drastic changes in …
associated with a progressive decline in memory and cognitive abilities, drastic changes in …
Alzheimer's associated inflammation, potential drug targets and future therapies
G Stuchbury, G Münch - Journal of Neural Transmission, 2005 - Springer
… in Alzheimer’s disease … target the cause of the disease rather than the symptoms. This
review describes the inflammatory pathways that are thought to be present in Alzheimer’s disease …
review describes the inflammatory pathways that are thought to be present in Alzheimer’s disease …
Focusing the amyloid cascade hypothesis on N-truncated Abeta peptides as drug targets against Alzheimer's disease
… Alzheimer’s disease, their potential as targets for pharmacological intervention has only
recently been investigated. In the last few years, the Alzheimer … etiology of Alzheimer’s disease, …
recently been investigated. In the last few years, the Alzheimer … etiology of Alzheimer’s disease, …
ACAT as a drug target for Alzheimer's disease
HJ Huttunen, DM Kovacs - Neurodegenerative Diseases, 2008 - karger.com
Accumulation of β-amyloid peptide (Aβ) in the brain regions responsible for memory and
cognitive functions is a neuropathological hallmark of Alzheimer’s disease. Cholesterol may be …
cognitive functions is a neuropathological hallmark of Alzheimer’s disease. Cholesterol may be …
New pathways identify novel drug targets for the prevention and treatment of Alzheimer's disease
B Penke, M Szűcs, F Bogár - International Journal of Molecular Sciences, 2023 - mdpi.com
… Inhibition of the formation of toxic Aβ and pTau aggregates has been an old drug target. …
for AD treatments if the disease is detected at early stages. More recently, novel targets, eg, …
for AD treatments if the disease is detected at early stages. More recently, novel targets, eg, …
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