Implications of GABAergic neurotransmission in Alzheimer's disease

Y Li, H Sun, Z Chen, H Xu, G Bu… - Frontiers in aging …, 2016 - frontiersin.org
… have strongly suggested that GABAergic neurotransmission plays very important roles in
AD pathogenesis. There’s close linkage between GABAergic signaling system and various …

GABAergic neurotransmission and new strategies of neuromodulation to compensate synaptic dysfunction in early stages of Alzheimer's disease

MO Nava-Mesa, L Jiménez-Díaz, J Yajeya… - Frontiers in cellular …, 2014 - frontiersin.org
… of different neurotransmission systems including recent findings regarding the GABAergic
system, … pharmacological strategies to compensate neurotransmission imbalance that might be …

Recent progress on the role of GABAergic neurotransmission in the pathogenesis of Alzheimer's disease

G Abbas, W Mahmood, N Kabir - Reviews in the Neurosciences, 2016 - degruyter.com
… Several interventional studies revealed the association between GABAergic neurotransmission
and AD (Table 1). GABA receptors, especially GABA A , are well known as a target for …

Treatment options in alzheimer s disease: the GABA story

M Solas, E Puerta, MJ Ramirez - Current pharmaceutical …, 2015 - ingentaconnect.com
… generally supports the view that GABA levels as well as GABAA … ing of GABAergic
neurotransmission in the human AD brain. … GABA levels in Alzheimer's disease and Down …

Towards a better understanding of GABAergic remodeling in Alzheimer's disease

K Govindpani, B Calvo-Flores Guzmán… - International journal of …, 2017 - mdpi.com
… of the glutamatergic and cholinergic neurotransmitter systems in Alzheimer’s disease (AD). …
of a GABAergic contribution to the pathogenesis of this neurodegenerative disease. Previous …

The GABAergic system as a therapeutic target for Alzheimer's disease

B Calvo‐Flores Guzmán, C Vinnakota… - Journal of …, 2018 - Wiley Online Library
… Up-regulating GABAergic neurotransmission using GABA A R agonists might thus represent
a promising strategy to reverse the hyperexcitability observed in AD and prevent cell loss. …

The GABAergic system in Alzheimer's disease: a systematic review with meta-analysis

G Carello-Collar, B Bellaver, PCL Ferreira… - Molecular …, 2023 - nature.com
neurotransmission system in the mammalian brain. In addition to the neurotransmitter GABA,
… (GAD) 65 and 67, GABA receptors (GABA A and GABA B ), GABA transporters (GAT) 1–3 …

Involvement of the GABAergic system in depressive symptoms of Alzheimer's disease

M Garcia-Alloza, SW Tsang, FJ Gil-Bea, PT Francis… - Neurobiology of …, 2006 - Elsevier
GABAergic neurotransmission in the cerebral cortex to both cognitive and non-cognitive
impairments in AD. Our working hypothesis for this study was that an imbalance between the …

Neurotransmitter imbalance in the brain and Alzheimer's disease pathology

SG Snowden, AA Ebshiana, A Hye… - … of Alzheimer's …, 2019 - content.iospress.com
… for Alzheimer’s disease (AD), and target the pathological reduction of acetylcholine levels.
Here we aimed to study the role of other neurotransmitter … In this study, GABA is increased in …

Astrocyte energy and neurotransmitter metabolism in Alzheimer's disease: integration of the glutamate/GABA-glutamine cycle

JV Andersen, A Schousboe, A Verkhratsky - Progress in neurobiology, 2022 - Elsevier
… pathology of Alzheimer’s disease (AD). Neurons and astrocytes function in close
collaboration through neurotransmitter recycling, collectively known as the glutamate/GABA-glutamine …