Mapping of a gene predisposing to early–onset Alzheimer's disease to chromosome 14q24. 3

C Van Broeckhoven, H Backhovens, M Cruts… - Nature …, 1992 - nature.com
… the genetic map positions of STR markers and AACT**. Although AACT was not included
in the genetic linkage map, we have put it next to the Pl gene since both these genes are …

The genetic defect causing familial Alzheimer's disease maps on chromosome 21

PH St George-Hyslop, RE Tanzi, RJ Polinsky… - Science, 1987 - science.org
disease, adult polycystic kidney disease, and cystic fibrosis, as well as several X-linked
disorders (9). We have applied the strategy of genetic … the FAD gene does map to chromosome …

A brief history of Alzheimer's disease gene discovery

RE Tanzi - Journal of Alzheimer's disease, 2013 - content.iospress.com
… (RFLPs) comprising our full genetic linkage map of chromosome 21. Our AD linkage results
for all RFLPs spanning our chromosome 21 genetic linkage map were entirely negative for …

Genome-wide meta-analysis, fine-mapping and integrative prioritization implicate new Alzheimer's disease risk genes

J Schwartzentruber, S Cooper, JZ Liu… - Nature …, 2021 - nature.com
gene expression, which probably occurs in a cell-type-dependent manner. A growing number
of studies have mapped genetic variants affecting gene … putative causal genetic variants …

Mapping the gene network landscape of Alzheimer's disease through integrating genomics and transcriptomics

SB Rosenthal, H Wang, D Shi, C Liu… - PLOS Computational …, 2022 - journals.plos.org
… processes, and is impacted significantly by genetic factors. Through integration of the … a
disease gene network that includes a total of 788 genes, and annotated 17 major gene clusters …

DNA methylation map of mouse and human brain identifies target genes in Alzheimer's disease

JV Sanchez-Mut, E Aso, N Panayotis, I Lott, M Dierssen… - Brain, 2013 - academic.oup.com
… models of Alzheimer’s disease. We were able to translate these findings to patients with
Alzheimer’s disease, identifying DNA methylation-associated silencing of three targets genes: …

Mapping the genetic landscape of early-onset Alzheimer's disease in a cohort of 36 families

MO Mol, SJ van der Lee, M Hulsman… - Alzheimer's Research & …, 2022 - Springer
Background Many families with clinical early-onset Alzheimer’s disease (EOAD) remain
genetically unexplained. A combination of genetic factors is not standardly investigated. In …

Gene identification in Alzheimer's disease

AM Saunders - Pharmacogenomics, 2001 - Taylor & Francis
… One outcome of identifying genetically relevant disease genes and mapping the human
genome’s SNPs will be the ability to help predict and improve a patient’s response to a medicine …

AD gene 3-D: moving past single layer genetic information to map novel loci involved in Alzheimer's disease

AJ Myers - Journal of Alzheimer's disease, 2012 - journals.sagepub.com
… The standard approach to mapping genes of interest in Alzheimer’s disease (AD) has … Prior
to the sequencing of the human genome, the main method for gene mapping involved family-…

Identification of risk genes for Alzheimer's disease by gene embedding

Y Lagisetty, T Bourquard, I Al-Ramahi, CG Mangleburg… - Cell genomics, 2022 - cell.com
… -gene interactions, even though these play a crucial role in complex, polygenic diseases
like Alzheimer’s disease (AD). To discover new genes whose interactions may contribute to …