… human amyloid-beta (Aβ) and other disease-relevant stressors. However, the vast majority
… disorders. The goal of this study was to test the hypothesis that brain p38α MAPK is a …

… p38 MAPK. More recently, Bhaskar’s group reported that a recently reported selective p38α
MAPK direct inhibitor 8 [78] suppresses p38α MAPK … impairment in aged hTau mice. Another …

… to develop selective inhibitors of p38α alone or both p38α and p38β for the … p38 MAPK is
exclusively localized in association with neurofibrillar pathology. Studies using transgenic mice …

… In mice that were double transgenic for mutant amyloid precursor … the MAP kinase families,
the p38 family members are activated by upstream dual-specificity kinases called MAP kinase …

… Treatment of old hTau mice with MW181 reduced activation of p38α MAPK and increased
expression of synaptophysin protein which resulted in improved working memory, supportive …

… We crossed the p38α∆-N mice with 5XFAD mice expressing two transgenes with AD
clinical mutations, an early-onset AD mouse model 28 . Indeed, at 2–3 months of age, 5XFAD …

… mice and inhibited by p38α-MAPK deficiency in myeloid cells in both early and late disease
… To further analyze the inflammatory activity of microglia in p38α-MAPK-deficient AD mice, we …

… In Alzheimer amyloid precursor protein-transgenic mice and … of mapk14, which encodes
p38α MAPK, a kinase sensitive to … that reduction of p38α MAPK expression facilitated the …

… of Alzheimer’s disease (AD), … mice, suggesting that p38α MAPK plays a role in the process
of Aβ deposition in vivo [71]. Moreover, the selective pharmacological inhibition of p38α MAPK …

… Alzheimer's disease (AD) is the leading cause of dementia with very limited therapeutic …
The cellular specificity of Cre-mediated p38α-MAPK deletion in neurons of APPtg mice …