… elevated MMP9 levels in AD brains and the reduced ability of apoE4 to modulate MMP9 …
to investigate the therapeutic value of modulating MMP9 activity in E4FAD transgenic animals, …

… modulate MMP-2 and MMP-9, and we evaluate their potential as therapeutic compounds
for neurodegenerative and neuroinflammatory diseases, with a focus on Alzheimer’s disease. …

… In conclusion, our findings suggest that sex modulates the influence of MMP-9 on AD-related
pathology and cognitive impairment and may crucially inform our understanding of the …

… Collectively, these data suggest that resveratrol decreases CSF MMP9, modulates neuro-…
A randomized, double-blind, placebo-controlled trial of resveratrol for Alzheimer disease. …

… Since MMP-9 did not alter the expression levels of IR or IRS1, we investigated modulation
of IRS1 by other factors. Previous reports have demonstrated that in primary neurons IRS1 …

… These properties could, henceforth, constitute MMP-9 as a novel modulator of insulin …
Thus, it is critical to characterize selective substrates for modulating MMP-9 expression. For …

… age in WT mice, whereas MMP-9 exhibited a significant decrease (… MMP-9, this increase
was also significant when compared to 6 months. Moreover, we found that MMP-2 and MMP-9 …

… Dendritic spine morphology and synaptic potentiation are dynamically modulated by
proteins of the ECM remodeling; which has an important role in synaptic plasticity [65]. …

… (Aβ), contributing to the onset of Alzheimer's disease (AD). While altered MMP … MMP9
modulation improves specific neurobehavioral deficits in a mouse model of Alzheimer’s disease…

… Alzheimer's disease pathology by increasing amyloid clearance through NO regulation of
MMP-9/… Our results demonstrated NO modulation of MMP-9/TIMP-1 balance and suggest that …