… pattern of myelin breakdown that recapitulates the developmental process of myelination
in reverse. The ensuing homeostatic responses to myelin breakdown further increase …

… broader overarching perspective of the myelin model of the human … myelin in addition to
neurons and synapses. The model proposes that the recently evolved and extensive myelination …

… myelin-centered model together with the technology that makes it possible to measure the
trajectory of myelin breakdown … to slow or reverse the breakdown process in both clinically …

… Age-related myelin breakdown: a developmental model of cognitive decline and … preclinical
risk for Alzheimer disease: linking beta-amyloid to myelin. JAMA Neurol 2017; 74: 17-9. 57. …

… Bartzokis by comparing a map of cortical myelination with maps of Aβ deposition hypothesized
that age-associated myelin breakdown leads to iron release from oligodendrocytes and …

… myelin restoration [Citation21,22,Citation25,26]. Research literature confirmed that myelin
breakdown … This work reviewed the role of myelin breakdown in cognitive decline and novel …

… conditions of myelin in the AD brain WM. However, ultrastructural observations in aged
nonhuman primates with memory deficits revealed myelin breakdown without axonal …

… It is defined as a subtotal tissue loss with a reduction of myelin, axons and oligodendrocytes
… myelin breakdown: a developmental model of cognitive decline and Alzheimer’s disease. …

… myelin breakdown in vulnerable late-myelinating regions releases oligodendrocyte- and
myelin-… in Alzheimer’s disease (AD). The model was tested by using published maps of cortical …

… injury may be closely related to neurodegenerative diseases and may be an early … signal
pathways of myelin injury in neurodegenerative diseases, especially the Alzheimer's disease to …