The neurovascular unit dysfunction in Alzheimer's disease

LO Soto-Rojas, M Pacheco-Herrero… - International Journal of …, 2021 - mdpi.com
… According to the vascular hypothesis of AD, vascular risk factors can result in dysregulation
of the neurovascular unit (NVU) and hypoxia. Hypoxia may reduce Aβ clearance from the …

The role of neurovascular unit damage in the occurrence and development of Alzheimer's disease

X Liu, DR Hou, FB Lin, J Luo, JW Xie… - Reviews in the …, 2019 - degruyter.com
… However, the role of neurovascular unit damage in the pathogenesis of AD has been attracting
… The composition of neurovascular unit and the role of neurovascular unit damage in the …

Neurovascular unit impairment in early Alzheimer's disease measured with magnetic resonance imaging

HJ van de Haar, JFA Jansen, MJP van Osch… - Neurobiology of …, 2016 - Elsevier
… The neurovascular unit, which protects neuronal … Alzheimer's Disease (AD). The aim of this
study was to noninvasively investigate 2 linked functional elements of the neurovascular unit, …

Shared molecular mechanisms among Alzheimer's disease, neurovascular unit dysfunction and vascular risk factors: a narrative review

L Falsetti, G Viticchi, V Zaccone, E Guerrieri… - Biomedicines, 2022 - mdpi.com
… cells) that are functionally organized in the neurovascular unit (NVU). The NVU is responsible
for so-called neurovascular coupling, an organized vascular response to specific neuronal …

Distinct changes in all major components of the neurovascular unit across different neuropathological stages of Alzheimer's disease

T Kirabali, R Rust, S Rigotti, A Siccoli… - Brain …, 2020 - Wiley Online Library
… form a structural and functional complex called neurovascular unit (NVU) which is critically
… alterations in the NVU across different Alzheimer's disease (AD) neuropathological stages. …

Contributions of blood–brain barrier imaging to neurovascular unit pathophysiology of Alzheimer's disease and related dementias

Y Uchida, H Kan, K Sakurai, K Oishi… - Frontiers in Aging …, 2023 - frontiersin.org
… of Alzheimer’s pathophysiology to establish novel imaging biomarkers and open new avenues
of interventions for Alzheimer’s disease … dynamics around the neurovascular unit in living …

Neurodegeneration and the neurovascular unit

BV Zlokovic - Nature medicine, 2010 - nature.com
disease 9 . It is possible that further study of the comorbidity factors that are associated with
Alzheimer's disease, … , cardiac disease and so on, will generate better correlates of human …

Locus Coeruleus and neurovascular unit: From its role in physiology to its potential role in Alzheimer's disease pathogenesis

FS Giorgi, A Galgani, S Puglisi‐Allegra… - Journal of …, 2020 - Wiley Online Library
… LC degenerates early during Alzheimer's disease (AD) and NA loss might concur to AD …
The term neurovascular unit (NVU) defines the strict anatomical/functional interaction …

Pathophysiology of the neurovascular unit: disease cause or consequence?

DB Stanimirovic, A Friedman - Journal of Cerebral Blood …, 2012 - journals.sagepub.com
… , the epidemiological studies showing a high degree of comorbidity among vascular disease
and dementias, including Alzheimer's disease, as well as migraine and epilepsy, suggested …

Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disorders

BV Zlokovic - Nature Reviews Neuroscience, 2011 - nature.com
… The neurovascular unit (NVU) comprises brain endothelial cells, pericytes or vascular …
Alzheimer's disease, and highlights therapeutic opportunities relating to these neurovascular