Targeting p38 MAPK pathway for the treatment of Alzheimer's disease
L Munoz, AJ Ammit - Neuropharmacology, 2010 - Elsevier
… is still missing, the p38 MAPK is emerging as a new Alzheimer's disease treatment strategy.
… on the role of p38 MAPK in neurodegeneration, with a focus on Alzheimer's disease, by …
… on the role of p38 MAPK in neurodegeneration, with a focus on Alzheimer's disease, by …
The p38 MAP kinase signaling pathway in Alzheimer's disease
GVW Johnson, CDC Bailey - Experimental neurology, 2003 - Elsevier
… One particularly important area of investigation is the contribution of aberrant cell signaling
… the p38 mitogenactivated protein (MAP) kinase signaling cascade is one signaling pathway …
… the p38 mitogenactivated protein (MAP) kinase signaling cascade is one signaling pathway …
[HTML][HTML] Recent advances in the inhibition of p38 MAPK as a potential strategy for the treatment of Alzheimer's disease
… inhibitors that can offer neuroprotection by mechanisms directly or indirectly involving the
p38 MAPK pathways. In the section on perspectives, the current status and limitation of …
p38 MAPK pathways. In the section on perspectives, the current status and limitation of …
Role of p38/MAPKs in Alzheimer's disease: implications for amyloid beta toxicity targeted therapy
… contributing to the pathology of neurodegenerative disorders including AD. Cumulative
evidence supports the role of p38 MAPK pathway activation in neuronal apoptosis in AD. …
evidence supports the role of p38 MAPK pathway activation in neuronal apoptosis in AD. …
P38 MAP kinase is activated at early stages in Alzheimer's disease brain
… postmortem tissue from control and Alzheimer’s disease (AD) cases at … Taken together, this
study demonstrates that p38 MAPK is … protein kinase (MAPK) signaling pathways. After being …
study demonstrates that p38 MAPK is … protein kinase (MAPK) signaling pathways. After being …
p38 kinase is activated in the Alzheimer's disease brain
K Hensley, RA Floyd, NY Zheng, R Nael… - Journal of …, 1999 - Wiley Online Library
… We have concentrated our studies on the p38 MAP kinase module, a prominent stress-activated
signal transduction pathway present ubiquitously in mammalian tissue and uniquely …
signal transduction pathway present ubiquitously in mammalian tissue and uniquely …
Peripheral expression of MAPK pathways in Alzheimer's and Parkinson's diseases
S Wang, C Zhang, X Sheng, X Zhang, B Wang… - Journal of Clinical …, 2014 - Elsevier
… of p38MAPK and JNK, which are located upstream in the cellular pathways controlling cell
… diseases. For this purpose, we determined the expression and phosphorylation status of …
… diseases. For this purpose, we determined the expression and phosphorylation status of …
[HTML][HTML] The PKR/P38/RIPK1 signaling pathway as a therapeutic target in Alzheimer's disease
J Hugon, C Paquet - International Journal of Molecular Sciences, 2021 - mdpi.com
… p38 MAPK is implicated in many pathological processes in the pathogenesis of AD [47].
Numerous studies have revealed that p38 MAPK … mouse model of Alzheimer disease. J. Biol. …
Numerous studies have revealed that p38 MAPK … mouse model of Alzheimer disease. J. Biol. …
[HTML][HTML] Involvement of p38 MAPK in synaptic function and dysfunction
C Falcicchia, F Tozzi, O Arancio, DM Watterson… - International journal of …, 2020 - mdpi.com
… of Alzheimer’s disease (AD), several studies have shown that the p38 MAPK cascade is …
In recent decades, many reports have shown that the p38 MAPK signaling pathway plays …
In recent decades, many reports have shown that the p38 MAPK signaling pathway plays …
[HTML][HTML] … inhibitor suppresses brain proinflammatory cytokine up-regulation and attenuates synaptic dysfunction and behavioral deficits in an Alzheimer's disease …
L Munoz, HR Ranaivo, SM Roy, W Hu, JM Craft… - Journal of …, 2007 - Springer
… p38 MAPK pathway is also seen in AD-relevant animal models [47–51]. However, causative
linkages between MAPK pathway … for further interaction with the p38 MAPK active site, we …
linkages between MAPK pathway … for further interaction with the p38 MAPK active site, we …
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