… This brief review will focus on p38 mitogen-activated protein kinase as a possible target
for … , oxidative stress, and cell cycle-related events in Alzheimer disease. J. Neuropathol. …

… p38 mitogen-activated protein kinase (MAPK) could play more than one role in Alzheimer's
disease … that patients suffering from AD dementia could benefit from p38 MAPK inhibitors. The …

… For example, recent findings have provided strong evidence that the p38 mitogen-activated
protein (MAP) kinase signaling cascade is one signaling pathway that may be overactivated …

… 51 Coogan AN, O’Neill LA, O’Connor JJ: The P38 mitogen-… ERK, JNK/SAPK and p38 in
Alzheimer disease: The ‘two hit’ … cell death, in Alzheimer disease, Pick’s disease, progressive …

… We now report evidence that the p38 mitogen-activated protein (MAP) kinase pathway, a
major proinflammatory signal transduction pathway activated by oxidants, cytokines, and AP, is …

… mitogenic and stress signaling cascades converge, we focused on one of the downstream
effectors of activated ERK and p38, mitogen- … strongly with activated p38 but only weakly with …

… In this review we describe in vivo evidence implicating that p38 and p44/… diseases, such as
Alzheimer's disease. We also clarify the extracellular signals responsible for activation of p38 …

… P38 mitogen-activated protein kinase (MAPK) is a crucial target for chronic inflammatory …
of p38 MAPK inhibitors in inflammatory diseases such as rheumatoid arthritis and asthma. P38 …

… Alzheimer disease (AD) demonstrates that oxidative stress is among the earliest events in the
disease. … disease are clear at this point. To begin to address these issues, we investigated …

… p38 MAPK (p-p38) and a phosphomimetic mutant of p38 MAPK in a … of p38 MAPK plays
pivotal roles in the pathophysiology of Alzheimer’s disease (AD), selective degradation of p-p38 …