PI3K/AKT signal pathway: a target of natural products in the prevention and treatment of Alzheimer's disease and Parkinson's disease

HZ Long, Y Cheng, ZW Zhou, HY Luo… - Frontiers in …, 2021 - frontiersin.org
… by activating PI3K/AKT pathway, … AKT signaling pathway and AD and PD, and discusses
the potential natural products based on the PI3K/AKT signaling pathway to treat two diseases in …

[HTML][HTML] The PI3K/Akt signaling axis in Alzheimer's disease: a valuable target to stimulate or suppress?

E Razani, A Pourbagheri-Sigaroodi… - Cell Stress and …, 2021 - Elsevier
… possibility of the PI3K/Akt/mTOR modulators… PI3K/Akt signaling axis in the progression or
repression of AD widely depends on the context of the cells; generally speaking, while PI3K/Akt

Dietary regulation of PI3K/AKT/GSK-3β pathway in Alzheimer's disease

Y Kitagishi, A Nakanishi, Y Ogura… - Alzheimer's research & …, 2014 - Springer
Alzheimer’s disease (AD) is characterized by the formation of … The PI3K/AKT/GSK-3β pathway
has been shown to play a … advances in the involvement of the PI3K/AKT/GSK-3β pathways …

Implications of phosphoinositide 3-kinase-Akt (PI3K-Akt) pathway in the pathogenesis of Alzheimer's disease

M Kumar, N Bansal - Molecular neurobiology, 2022 - Springer
… Recently, phosphoinositide 3-kinase (PI3K) and Akt are … PI3K-Akt pathway in AD and agents
which may modulate Akt … using keywords “PI3K-Akt” and “Alzheimer’s disease” from PubMed…

Mini‐review: Role of the PI3K/Akt pathway and tyrosine phosphatases in Alzheimer's disease susceptibility

D Curtis, S Bandyopadhyay - Annals of Human Genetics, 2021 - Wiley Online Library
… hypothesis that one contribution to pathogenesis in Alzheimer's disease (AD) is enhanced …
of the PI3K/Akt signaling pathway. A number of tyrosine phosphatases act to reduce PI3K/Akt

The role of PI3K/AKT pathway and its therapeutic possibility in Alzheimer's disease

HJ Yu, SH Koh - Hanyang Medical Reviews, 2017 - synapse.koreamed.org
Alzheimer's disease (AD) is the most common form of dementia. Although … (PI3K)/AKT
pathway. In this review, questions on the two hypotheses, the definition of the PI3K/AKT pathway, …

Altered insulin signaling in Alzheimer's disease brain–special emphasis on PI3K-Akt pathway

S Gabbouj, S Ryhänen, M Marttinen… - Frontiers in …, 2019 - frontiersin.org
… to the insulin-PI3K-Akt signaling pathway. The aim in this review article is to summarize and
discuss the effects of altered insulin-PI3K-Akt signaling and T2D on the pathogenesis of AD. …

Neuroprotective effects of salidroside through PI3K/Akt pathway activation in Alzheimer's disease models

B Zhang, Y Wang, H Li, R Xiong, Z Zhao… - Drug design …, 2016 - Taylor & Francis
… the PI3K/Akt signaling pathway that plays a crucial role in promoting neuronal survival under
a variety of circumstances. Citation20 We measured Akt … exhibited decreased p-Akt, and Sal …

Inhibition of PTEN attenuates endoplasmic reticulum stress and apoptosis via activation of PI3K/AKT pathway in Alzheimer's disease

W Cui, S Wang, Z Wang, Z Wang, C Sun… - Neurochemical …, 2017 - Springer
… activation of the PI3K/AKT pathway, we treated APP/PS1 transgenic mice with AKT inhibitor
in … Bpv treatment increased the ratio of p-AKT/AKT compared with vehicle group (Fig. 6). The …

PI3-kinase/Akt/mTOR signaling: impaired on/off switches in aging, cognitive decline and Alzheimer's disease

C O'Neill - Experimental gerontology, 2013 - Elsevier
… /Akt pathway has significant functional impact on key events that go awry in Alzheimer's disease
(… Investigation of the status of the PI3-K/Akt system in brains of individuals who have had …