Diagnostic performance and prediction of clinical progression of plasma phospho-tau181 in the Alzheimer's Disease Neuroimaging Initiative

…, Alzheimer's Disease Neuroimaging Initiative - Molecular …, 2021 - nature.com
… baseline plasma p-tau181plasma p-tau181 can predict future progression to dementia in
a larger cohort of individuals followed over longer periods. The relevance of plasma p-tau181

Plasma P-tau181 in Alzheimer's disease: relationship to other biomarkers, differential diagnosis, neuropathology and longitudinal progression to Alzheimer's dementia

S Janelidze, N Mattsson, S Palmqvist, R Smith… - Nature medicine, 2020 - nature.com
… High plasma P-tau181 was associated with subsequent … In conclusion, plasma P-tau181
is a noninvasive diagnostic … how plasma P-tau181 correlates with CSF P-tau181 and …

Plasma phospho-tau181 in presymptomatic and symptomatic familial Alzheimer's disease: a longitudinal cohort study

A O'Connor, TK Karikari, T Poole, NJ Ashton… - Molecular …, 2021 - nature.com
Plasma p-tau181 showed considerable intra-individual … From a fitted model there was
evidence (p = 0.050) that p-tau181 … Our finding that plasma p-tau181 concentration is increased …

Longitudinal plasma phosphorylated tau 181 tracks disease progression in Alzheimer's disease

…, Alzheimer's Disease Neuroimaging Initiative - Translational …, 2021 - nature.com
… The study involved 1184 people from the Alzheimer disease neuroimaging initiative (ADNI) …
We hypothesized that plasma p-tau181 levels would increase over time with disease

Plasma phospho-tau181 increases with Alzheimer's disease clinical severity and is associated with tau-and amyloid-positron emission tomography

MM Mielke, CE Hagen, J Xu, X Chai, P Vemuri… - Alzheimer's & …, 2018 - Elsevier
… of plasma phospho-tau181 (pTau181) and plasma total tau by clinical diagnosis across the
AD spectrum; (2) examine the associations between plasma pTau181 … of plasma pTau181 or …

Plasma ptau181, p‐tau217, and other blood‐based Alzheimer's disease biomarkers in a multi‐ethnic, community study

AM Brickman, JJ Manly, LS Honig… - Alzheimer's & …, 2021 - Wiley Online Library
… Our focus was on the current state-of-the-art AD-related plasma biomarkers, including …
tau (p-tau) 181 and 217 as markers of tau pathology. We compared plasma biomarker …

Sex differences in plasma p-tau181 associations with Alzheimer's disease biomarkers, cognitive decline, and clinical progression

…, Alzheimer's Disease Neuroimaging Initiative - Molecular …, 2022 - nature.com
plasma p-tau181 levels, relative to men. Our results suggest that sex may impact the clinical
interpretation of plasma p-tau181 … for the use of plasma p-tau181 as an accessible AD …

Plasma p-tau181 accurately predicts Alzheimer's disease pathology at least 8 years prior to post-mortem and improves the clinical characterisation of cognitive decline

J Lantero Rodriguez, TK Karikari, M Suárez-Calvet… - Acta …, 2020 - Springer
plasma p-tau181 specifically reflects AD pathology in neuropathologically confirmed cases,
(2) if plasma p-tau181 … the longitudinal trajectories of plasma p-tau181 are different between …

The diagnostic and prognostic capabilities of plasma biomarkers in Alzheimer's disease

…, M Schöll, P Mecocci… - Alzheimer's & …, 2021 - Wiley Online Library
… diagnostic and prognostic utility of plasma P-tau181 as compared to other putative plasma
biomarkers (Aβ42/Aβ40, NfL, T-tau, and GFAp) of AD. Plasma P-tau181 has potential value in …

Plasma neurofilament light and phosphorylated tau 181 as biomarkers of Alzheimer's disease pathology and clinical disease progression

C Clark, P Lewczuk, J Kornhuber, J Richiardi… - Alzheimer's research & …, 2021 - Springer
plasma NfL and plasma p-tau181 levels, or the combination thereof, to serve as blood-based
biomarkers for the diagnosis of cerebral AD pathology and the prediction of clinical disease