The serotonin 5-HT4 receptor mediates many physiological effects in the central nervous …
identification of 5-HT4 receptors and the development of selective 5-HT4 receptor ligands have …

… Our data suggests that the cerebral 5HT4 receptor upregulation starts at a preclinical stage
and continues, at least as long as dementia is still at a mild stage. Locally, the upregulation of …

… 5-HT4 receptor is a G protein coupled receptor (GPCR) which belongs to serotonin receptor
family … the role of 5-HT4 receptor agonists for treatment of gastro-intestinal (GI) spectrum of …

… The pathological hallmarks of Alzheimer's disease are extracellular Amyloid plaques and
intracellular neurofibrillary tangles. Ap, Amyloid protein fragment; APP, Amyloid Precursor …

… that 5HT4 binding sites increase in number after the innervation by serotonin neurons has …
suggest a possible cotreatment in Alzheimer's disease and offer the possibility of reducing the …

… deficits in the 5XFAD mouse model of Alzheimer's disease. Front. Aging Neurosci… Serotonin
5-HT6 receptor antagonists for the treatment of cognitive deficiency in Alzheimer's disease…

… Indeed, PET studies showed a correlation between the body mass index and 5-HT 4 R …
5-HT 4 receptors was found to be decreased in the temporal cortex of Alzheimer’s disease …

… in learning and memory and it is suggested that 5-HT 4 agonists may be beneficial for memory
disorders such as Alzheimer's disease (AD). The 5-HT 4 receptors are members of the G …

… The serotonin 5-HT 4 receptor has recently gained a lot of attention … of the human 5-HT 4
(h5-HT 4 ) receptor stimulates the … open a new avenue for the treatment of Alzheimer's disease. …

… serotonin receptors in learning and memory has improved. 5-HT 1A , 5-HT 4 and 5-HT 6
receptors … and neurodegenerative diseases such as Parkinson's and Alzheimer's disease. There …